Catenin beta-1
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Catenin beta-1, also known as β-catenin, is a protein that in humans is encoded by the CTNNB1 gene.
2bct murinebcat
β-catenin immunohistochemistry in solid pseudopapillary tumor, staining the nuclei in 98% of such cases. Cytoplasm is also staining in this case.
Immunohistochemistry for β-catenin in uterine leiomyoma, which is negative as there is only staining of cytoplasm but not of cell nuclei. This is a consistent finding, which helps in distinguishing such tumors from β-catenin positive spindle cell tumors.
Likewise, negative nuclear staining is seen in approximately 95% of gastrointestinal stromal tumors.
Lymphoid enhancer-binding factor 1 is a protein that in humans is encoded by the LEF1 gene. It is a member of T cell factor/lymphoid enhancer factor family.
Catenin beta-1
…players. Notably, the C-terminal segment of β-catenin can mimic the effects of the entire Wnt pathway if artificially fused to the DNA binding domain of LEF1 transcription factor. Plakoglobin (also called γ-catenin) has a strikingly similar architecture to that of β-catenin. Not only their ARM domains resemble…
The implication of LEF1 short and long isoforms in Transcriptional Regulation
LEF1 Expression in Human Lung Tissue Lysates
2lef: LEF1 HMG DOMAIN (FROM MOUSE), COMPLEXED WITH DNA (15BP), NMR, 12 STRUCTURES