The Cathedral Basilica of Saint Francis of Assisi, commonly known as Saint Francis Cathedral, is a Roman Catholic cathedral in downtown Santa Fe, New Mexico. It is the mother church of the Archdiocese of Santa Fe.

Santa Fe is the capital of the U.S. state of New Mexico. With a population of 87,505 at the 2020 census, it is the fourth-most populous city in the state. It is also the county seat of Santa Fe County. Its metropolitan area is part of the Albuquerque–Santa Fe–Los Alamos combined statistical area, which had a population of 1,162,523 in 2020. Human settlement dates back thousands of years in the region. The city was founded in 1610 as the capital of Nuevo México, replacing previous capitals at San Juan de los Caballeros and San Gabriel de Yunque; this makes it the oldest state capital in the United States.