The Cathedral of Saint James is a 12th-century Armenian church in the Armenian Quarter of Jerusalem, near the quarter's entry Zion Gate. The cathedral is dedicated to two of the Twelve Apostles of Jesus: James, son of Zebedee and James the brother of Jesus. It is located near the Church of the Holy Archangels.

The Armenian Quarter is one of the four sectors of the walled Old City of Jerusalem. Located in the southwestern corner of the Old City, it can be accessed through the Zion Gate and Jaffa Gate. It occupies an area of 0.126 km², which is 14% of the Old City's total. In 2007, it had a population of 2,424. In both criteria, it is comparable to the Jewish Quarter. The Armenian Quarter is separated from the Christian Quarter by David Street and from the Jewish Quarter by Habad Street.