The Cathedral of Santa María la Menor in the Colonial City of Santo Domingo is dedicated to St. Mary of the Incarnation. It is the first and oldest cathedral in the Americas, begun in 1504 and was completed in 1550. It is the cathedral of the Archbishop of Santo Domingo who has the honorary title of Primate of the Indies because this cathedral was the first diocese and the oldest cathedral established in the New World.

Ciudad Colonial is the historic central neighborhood of the Dominican Republic's capital Santo Domingo. It is the oldest continuously inhabited European-established settlement in the Americas. The area has been declared a World Heritage Site by UNESCO. It is also known as Zona Colonial or more colloquially as "La Zona".