The Cathedral of the Holy Spirit is a cathedral and parish church of the Catholic Church located in Bismarck, North Dakota, United States. It is the seat of the Diocese of Bismarck. Since 1980, the cathedral and the nearby Bishop's Residence have been contributing properties in the Bismarck Cathedral Area Historic District on the National Register of Historic Places.

Bismarck is the capital of the U.S. state of North Dakota and the county seat of Burleigh County. It is the state's 2nd most populous city, after Fargo. The population was 73,622 at the 2020 census, and was estimated to be 74,445 in 2022, while its metropolitan population was 133,626. In 2020, Forbes magazine ranked Bismarck as the seventh fastest-growing small city in the United States.