The Cathedral of the Nativity of Our Lady also Sé Catedral da Natividade de Nossa Senhora and Igreja da Sé is a Roman Catholic cathedral in Sé, Macau. It is the current cathedral of the Diocese of Macau. The cathedral is also called the "Church of the Nativity of Our Lady".

Sé is a southeast civil parish in the Macau Peninsula of Macau. It is the second largest peninsular district in Macau after the civil parish of Nossa Senhora de Fátima. The parish area is named for the Igreja da Sé.