The Catholic Church and slavery have a long and complicated history. Slavery was practiced and accepted by many cultures and religions around the world throughout history, including in ancient Rome. Passages in the Old Testament sanctioned forms of temporal slavery for Israelites as a means to repay a debt. Slaves, captured in war or purchased, and their children were enslaved for life. After Christianity was legalized under the Roman empire, sentiment grew that many kinds of slavery were incompatible with Christian justice. Views ranged from rejecting all forms of slavery to accepting slavery subject to certain restrictions. The Christian West almost entirely enforced that a free Christian could not be enslaved, for example as a captive in war. However, this was not consistently applied throughout history. The Middle Ages witnessed the emergence of orders of monks such as the Mercedarians who focused on ransoming Christian slaves. By the end of the Medieval period, enslavement of Christians had been largely abolished throughout Europe, although enslavement of non-Christians remained permissible and was revived in Spain and Portugal. Slavery remained a subject of debate within the Church for centuries, with several Popes issuing bulls on the issue, such as Sublimis Deus.

The Bible contains many references to slavery, which was a common practice in antiquity. Biblical texts outline sources and the legal status of slaves, economic roles of slavery, types of slavery, and debt slavery, which thoroughly explain the institution of slavery in Israel in antiquity. The Bible stipulates the treatment of slaves, especially in the Old Testament. There are also references to slavery in the New Testament.