The Catholic Church in North Macedonia is part of the worldwide Catholic Church, under the spiritual leadership of the Pope in Rome and is one of the major religious communities that exist on the territory of the Republic of North Macedonia. Catholic believers from North Macedonia mostly include Albanians, Macedonians and Croats and are most concentrated in the Skopje Statistical Region and the Southeastern Statistical Region of North Macedonia.

The Skopje Statistical Region is one of eight Statistical regions of North Macedonia. Skopje, located in the north of the country, borders Kosovo to the north. Internally, it borders the Vardar, Polog, Northeastern, Eastern, and Southwestern statistical regions.