Cats & Dogs: The Revenge of Kitty Galore is a 2010 spy comedy film directed by Brad Peyton in his directorial debut, produced by Andrew Lazar, Polly Johnsen, Greg Michael and Brent O'Connor and written by Ron J. Friedman and Steve Bencich based on the characters by John Requa and Glenn Ficarra. The film stars Chris O'Donnell and Jack McBrayer with an ensemble voice cast of James Marsden, Nick Nolte, Christina Applegate, Katt Williams, Bette Midler, Neil Patrick Harris, Sean Hayes, Joe Pantoliano, Michael Clarke Duncan, Wallace Shawn and Roger Moore. The film is a stand-alone sequel to the 2001 film Cats & Dogs, with more emphasis on its animal characters than the previous film, and was released on July 30, 2010, by Warner Bros. Pictures. It received mostly negative reviews from film critics and grossed $112.5 million on an $85 million budget.

Brad Peyton is a Canadian filmmaker, best known for directing the Dwayne Johnson star vehicles Journey 2: The Mysterious Island (2012), San Andreas (2015), and Rampage (2018) as well as the Netflix series Daybreak (2019).