On February 4, 2018, the southbound Amtrak Silver Star No. 91 passenger train from New York City to Miami collided with a stationary CSX Transportation freight train in Cayce, South Carolina, just south of the state's capital of Columbia on CSX's Columbia Subdivision. Two Amtrak crew members were killed and 116 other crew and passengers were injured.

The Silver Star is a long-distance passenger train operated by Amtrak on a 1,522-mile (2,449 km) route between New York City and Miami via Washington, D.C., Richmond, Virginia, Raleigh, North Carolina, Columbia, South Carolina, Savannah, Georgia, Jacksonville, Florida, and Tampa, Florida. The Silver Star and its sister train in the Silver Service brand, the Silver Meteor, are the descendants of numerous long-distance trains that operated between Florida and New York for most of the 20th century.