The Cayuga are one of the five original constituents of the Haudenosaunee (Iroquois), a confederacy of Native Americans in New York. The Cayuga homeland lies in the Finger Lakes region along Cayuga Lake, between their league neighbors, the Onondaga to the east and the Seneca to the west. Today, Cayuga people belong to the Six Nations of the Grand River First Nation in Ontario, and the federally recognized Cayuga Nation of New York and the Seneca-Cayuga Tribe of Oklahoma.

The Iroquois, also known as the Five Nations, and later as the Six Nations from 1722 onwards; alternatively referred to by the endonym Haudenosaunee are an Iroquoian-speaking confederacy of Native Americans and First Nations peoples in northeast North America. They were known by the French during the colonial years as the Iroquois League, and later as the Iroquois Confederacy, while the English simply called them the "Five Nations". The peoples of the Iroquois included the Mohawk, Oneida, Onondaga, Cayuga, and Seneca. After 1722, the Iroquoian-speaking Tuscarora people from the southeast were accepted into the confederacy, from which point it was known as the "Six Nations".