The Cayuse Five were five members of the Native American tribe, the Cayuse of Oregon who were hanged for murder, in 1850. Their names were Clokomas, Isiaasheluckas, Kiamasumkin, Telakite, and Tomahas—note how these names are spelled varies.

The Cayuse are a Native American tribe in what is now the state of Oregon in the United States. The Cayuse tribe shares a reservation and government in northeastern Oregon with the Umatilla and the Walla Walla tribes as part of the Confederated Tribes of the Umatilla Indian Reservation. The reservation is located near Pendleton, Oregon, at the base of the Blue Mountains.