Centennial is a home rule municipality located in Arapahoe County, Colorado, United States. The city population was 108,418 at the 2020 United States Census, making Centennial the 11th most populous municipality in Colorado. Centennial is a part of the Denver–Aurora–Lakewood, CO Metropolitan Statistical Area and the Front Range Urban Corridor.

In the US state of Colorado, Interstate 25 (I-25) follows the north–south corridor through Colorado Springs and Denver. The highway enters the state from the north near Carr and exits the state near Starkville. The highway also runs through the cities of Fort Collins, Broomfield, Loveland, and Pueblo. The route is concurrent with U.S. Route 87 (US 87), which is unsigned, through the entire length of the state. I-25 replaced US 87 and most of US 85 for through traffic.