The Centennial National Bank is a historic building in Philadelphia, Pennsylvania. Designed by noted Philadelphia architect Frank Furness and significant in his artistic development, it was built in 1876 as the headquarters of the eponymous bank that would be the fiscal agent of the Centennial Exposition. The building housed a branch of the First Pennsylvania Bank from 1956 until Drexel University purchased it c. 1976. Drexel renovated it between 2000-2002 and now uses it as an alumni center. The Centennial National Bank, described as "one of the best pieces of architecture in West Philadelphia," was placed on the National Register of Historic Places in 1971.

Frank Heyling Furness was an American architect of the Victorian era. He designed more than 600 buildings, most in the Philadelphia area, and is remembered for his diverse, muscular, often inordinately scaled buildings, and for his influence on the Chicago-based architect Louis Sullivan. Furness also received a Medal of Honor for bravery during the Civil War.