Central Region, also known as the Ma'ekel or Maakel Region, is an administrative region of Eritrea, located in central Eritrea. The region was formed on 15 April 1996, from the historical province of Hamasien. The region is located on the central plateau, and sits at an average of about 2,250 metres (7,380 ft) above sea level. It contains Asmara, the capital and largest city of Eritrea.

The regions of Eritrea are the primary geographical divisions through which Eritrea is administered. Six in total, they include the Central, Anseba, Gash-Barka, Southern, Northern Red Sea and Southern Red Sea regions.