Centre-Val de Loire or Centre Region, as it was known until 2015, is one of the eighteen administrative regions of France. It straddles the middle Loire Valley in the interior of the country, with a population of 2,572,853 as of 2018. Its prefecture is Orléans, and its largest city is Tours.

The Loire Valley, spanning 280 kilometres (170 mi), is a valley located in the middle stretch of the Loire river in central France, in both the administrative regions Pays de la Loire and Centre-Val de Loire. The area of the Loire Valley comprises about 800 square kilometres (310 sq mi). It is referred to as the Cradle of the French and the Garden of France due to the abundance of vineyards, fruit orchards, and artichoke, and asparagus fields, which line the banks of the river. Notable for its historic towns, architecture, and wines, the valley has been inhabited since the Middle Palaeolithic period. The oldest known Neanderthal engravings have been found a cave in La Roche-Cotard which have been dated to more than 57,000 years ago. In 2000, UNESCO added the central part of the Loire River valley to its list of World Heritage Sites.