Centrocyte
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In immunology, a centrocyte generally refers to a B cell with a cleaved nucleus, as may appear in e.g. follicular lymphoma. Centrocytes are B cells that are found in the light zones of germinal center
Histopathology of centrocytes in a follicular lymphoma. They have a thick nuclear membrane and prominent nucleoli.
Histologic comparison of cell types in a germinal center, H&E stain: - Centrocytes are small to medium size with angulated, elongated, cleaved, or twisted nuclei. - Centroblasts are larger cells containing vesicular nuclei with one to three basophilic nucleoli apposing the nuclear membrane. - Follicular dendritic cells have round nuclei, centrally located nucleoli, bland and dispersed chromatin, and flattening of adjacent nuclear membrane.
Follicular dendritic cells
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Follicular dendritic cells are cells of the immune system found in primary and secondary lymph follicles of the B cell areas of the lymphoid tissue. Unlike dendritic cells, FDCs are not derived from t
Centrocyte
…or twisted nuclei. - Centroblasts are larger cells containing vesicular nuclei with one to three basophilic nucleoli apposing the nuclear membrane. - Follicular dendritic cells have round nuclei, centrally located nucleoli, bland and dispersed chromatin, and flattening of adjacent nuclear membrane. The dark zone of germinal…
This is an isolated Follicular Dendritic Cell cultured on collagen. It shows a cell body and numerous dendritic cell processes interdigitating with one another and with dendrites of adjacent FDCs to form a network. This network traps antigen in the form of immune complexes and helps initiate an antibody response by B cells