Cesare Vincenzo Orsenigo was Apostolic Nuncio to Germany from 1930 to 1945, during the rise of Nazi Germany and World War II. Along with the German ambassador to the Vatican, Diego von Bergen and later Ernst von Weizsäcker, Orsenigo was the direct diplomatic link between Pope Pius XI and Pope Pius XII and the Nazi regime, meeting several times with Adolf Hitler directly and frequently with other high-ranking officials and diplomats.

The Apostolic Nunciature to Germany is an ecclesiastical office of the Roman Catholic Church in Germany. It is a diplomatic post of the Holy See, whose representative is called the Apostolic Nuncio to Germany with the rank of an ambassador. The office of the nunciature has been located in Berlin since 1925, in union with the new Apostolic Nuncio to Prussia until 1934. Between 1920 and 1925 the nunciature was held in personal union by the Apostolic Nuncio to Bavaria, seated in Munich. With the unconditional surrender of Germany in 1945 the diplomatic ties were interrupted and reestablished for West Germany only in 1951, then in Bonn. In 2001 the nunciature moved again to Berlin.