Chalcis railway station is a railway station in the city of Chalcis, in Euboea, Greece. Opened on 8 March 1904, it is now the northern terminus station of the Athens - Chalcis service of Proastiakos. The station sits close to the waterfront, with a small promenade running parallel to the platforms. It is owned by OSE, but services are provided by Hellenic Train through the Athens Suburban Railway to Oinoi and Athens.

Chalcis (; Ancient Greek & Katharevousa: Χαλκίς, romanized: Chalkís), also called Chalkida or Halkida (Modern Greek: Χαλκίδα, pronounced [xalˈciða]), is the chief city of the island of Euboea or Evia in Greece, situated on the Euripus Strait at its narrowest point. The name is preserved from antiquity and is derived from the Greek χαλκός (copper, bronze), though there is no trace of any mines in the area. In the Late Middle Ages, it was known as Negropont(e), an Italian name that has also been applied to the entire island of Euboea.