Characene, also known as Mesene (Μεσσήνη) or Meshan, was a kingdom founded by the Iranian Hyspaosines located at the head of the Persian Gulf mostly within modern day Iraq. Its capital, Charax Spasinou, was an important port for trade between Mesopotamia and India, and also provided port facilities for the city of Susa further up the Karun River. The kingdom was frequently a vassal of the Parthian Empire. Characene was mainly populated by Arabs, who spoke Aramaic as their cultural language. All rulers of the principality had Iranian names. Members of the Arsacid dynasty also ruled the state.

Hyspaosines was the founder of Characene, a kingdom situated in southern Mesopotamia. He was originally a Seleucid satrap installed by king Antiochus IV Epiphanes, but declared independence in 141 BC after the collapse and subsequent transfer of Seleucid authority in Iran and Babylonia to the Parthians. Hyspaosines briefly occupied the Parthian city of Babylon in 127 BC, where he is recorded in records as king (šarru). In 124 BC, however, he was forced to acknowledge Parthian suzerainty. He died in the same year, and was succeeded by his juvenile son Apodakos.