Charlene Barshefsky served as United States Trade Representative, the country's top trade negotiator, from 1997 to 2001. She was the Deputy U.S. Trade Representative from 1993 to 1997. She is a partner at the law firm of Wilmer Cutler Pickering Hale and Dorr. She is also an advisor at Moelis & Company and a participant of the Task Force on U.S.-China Policy convened by the Asia Society's Center on US-China Relations.

The Office of the United States Trade Representative (USTR) is an agency of the United States federal government responsible for developing and promoting American trade policy. Part of the Executive Office of the President, it is headed by the U.S. Trade Representative, a Cabinet-level position that serves as the U.S. President's primary advisor, negotiator, and spokesperson on trade matters. USTR has more than two hundred employees, with offices in Geneva, Switzerland, and Brussels, Belgium.