Charles de Bourbon was a French prince du sang and military commander at the court of Francis I of France.

A prince du sang or prince of the blood is a person legitimately descended in male line from a sovereign. The female equivalent is princess of the blood, being applied to the daughter of a prince of the blood. The most prominent examples include members of the French royal line, but the term prince of the blood has been used in other families more generally, for example among the British royal family and when referring to the Shinnōke in Japan.