Charles II, Count of Hohenzollern-Sigmaringen (German: Karl II, Graf von Hohenzollern-Sigmaringen) became Count of Hohenzollern-Sigmaringen in 1576 and remained so until his death. He was the fifth but second surviving son of Charles I, Count of Hohenzollern, and Anna, daughter of Ernest, Margrave of Baden-Durlach.

Hohenzollern-Sigmaringen was a principality in southwestern Germany. Its rulers belonged to the senior Swabian branch of the House of Hohenzollern. The Swabian Hohenzollerns were elevated to princes in 1623. The small sovereign state with the capital city of Sigmaringen was annexed to the Kingdom of Prussia in 1850 following the abdication of its sovereign in the wake of the revolutions of 1848, then became part of the newly created Province of Hohenzollern.