Charles III, known as the Great, was Duke of Lorraine from 1545 until his death.

Christina of Denmark was a Danish princess, the younger surviving daughter of King Christian II of Denmark and Norway and Isabella of Austria. By her two marriages, she became Duchess of Milan, then Duchess of Lorraine. She served as the regent of Lorraine from 1545 to 1552 during the minority of her son. She was also a claimant to the thrones of Denmark, Norway and Sweden in 1561–1590 and was sovereign Lady of Tortona in 1578–1584.