Charles Reginald Jackson was an American writer. He wrote the 1944 novel The Lost Weekend.

The Lost Weekend is Charles R. Jackson's first novel, published by Farrar & Rinehart in 1944. The story of a talented but alcoholic writer was praised for its powerful realism, closely reflecting the author’s own experience of alcoholism, from which he was temporarily cured. It served as the basis for the classic 1945 Oscar winning film adaptation.