Charles Street, known for most of its route as Maryland Route 139, runs through Baltimore and the Towson area of Baltimore County. On the north end, it terminates at an intersection with Bellona Avenue near Interstate 695 (I-695). At the south end, it terminates in Federal Hill in Baltimore. Charles Street is one of the major routes through Baltimore, and is a major public transportation corridor. For the one-way portions of Charles Street, the street is functionally complemented by the parallel St. Paul Street, including St. Paul Place and Preston Gardens, Maryland Avenue, Cathedral Street, and Liberty Street.

Interstate 695 (I-695) is a 51.46-mile-long (82.82 km) auxiliary Interstate Highway that constitutes a beltway extending around Baltimore, Maryland, United States. I-695 is officially designated the McKeldin Beltway but is colloquially referred to as either the Baltimore Beltway or 695. The route is an auxiliary route of I-95, intersecting that route southwest of Baltimore near Arbutus and northeast of the city near White Marsh. It also intersects other major roads radiating from the Baltimore area, including I-97 near Glen Burnie, the Baltimore–Washington Parkway near Linthicum, I-70 near Woodlawn, I-795 near Pikesville, and I-83 in the Timonium area. The 19.37-mile (31.17 km) portion of the Baltimore Beltway between I-95 northeast of Baltimore and I-97 south of Baltimore is officially Maryland Route 695 (MD 695) and is not part of the Interstate Highway System but is signed as I-695. The Francis Scott Key Bridge that crossed over the Patapsco River was included in this section of the route before the bridge's collapse on March 26, 2024. The bridge and its approaches were maintained by the Maryland Transportation Authority (MDTA), while the remainder of the Baltimore Beltway is maintained by the Maryland State Highway Administration (MDSHA).