The Charles W. Goodyear House is located at 888 Delaware Avenue in Buffalo, New York, part of the Delaware Avenue Historic District, a federally designated historic district listed on the National Register of Historic Places since 1974. The Châteauesque house was designed by prominent Buffalo architect Edward Green, of the Buffalo architecture firm Green & Wicks, and was completed in 1903 at a cost of $500,000. The home was built for Charles and Ella Goodyear. Goodyear was a founder and head of several companies including the Buffalo and Susquehanna Railroad, Great Southern Lumber Company, and the New Orleans Great Northern Railroad Company, as well as a director of Marine National Bank, and General Railway Signal.

Anson Conger Goodyear was an American manufacturer, businessman, author, and philanthropist and member of the Goodyear family. He is best known as one of the founding members and first president of the Museum of Modern Art in New York.