Charlotte Amalie High School (CAHS) is a public high school housing a population of just over 1400 students, and over 130 members of faculty and staff. It is located in what is colloquially called the "town area" of the island of St. Thomas, United States Virgin Islands. It is named after the official name for the "town area," Charlotte Amalie. It is a part of the St. Thomas-St. John School District. It is the territory's most populous high school.

Charlotte Amalie, located on St. Thomas, is the capital and the 2nd largest city of the United States Virgin Islands. It was founded in 1666 as Taphus. In 1691, the town was renamed to Charlotte Amalie after the Danish queen Charlotte Amalie of Hesse-Kassel (1650–1714). It has a deep-water harbor that was once a haven for pirates and is now one of the busiest ports of call for cruise ships in the Caribbean, with about 1.5 million-plus cruise ship passengers landing there annually. Protected by Hassel Island, the harbor has docking and fueling facilities, machine shops, and shipyards and was a U.S. submarine base until 1966. The Town has been inhabited for centuries. When Christopher Columbus arrived in 1493, the area was inhabited by Caribs, Arawaks, Ciboney and Taíno native peoples. It is on the southern shore at the head of Saint Thomas Harbor. In 2010 the City had a population of 18,481, which makes it the largest city in the Virgin Islands Archipelago. Hundreds of ferries and yachts pass by the Town each week.