Charlotte Saunders Cushman was an American stage actress. Her voice was noted for its full contralto register, and she was able to play both male and female parts. She lived intermittently in Rome, in an expatriate colony of prominent artists and sculptors, some of whom became part of her tempestuous private life.

Lady Macbeth is a leading character in William Shakespeare's tragedy Macbeth. As the wife of the play's tragic hero, Macbeth, Lady Macbeth goads her husband into committing regicide, after which she becomes queen of Scotland. Some regard her as becoming more powerful than Macbeth when she does this, because she is able to manipulate him into doing what she wants. After Macbeth becomes a murderous tyrant, she is driven to madness by guilt over their crimes and kills herself offstage.