Charlotte Harbor Estuary, the second largest bay in Florida, is located on the Gulf of Mexico coast of west Florida with two thirds lying in Charlotte County, Florida and one in Lee County. The harbor's mouth is located behind Gasparilla Island, one of the many coastal barrier islands on the southwest coast of Florida, with access from the Gulf of Mexico through the Boca Grande Pass between Gasparilla Island on the north and Lacosta Island on the south. Charlotte Harbor covers about 270 sq mi (700 km2)

Charlotte County is a U.S. county located in southwestern Florida. As of the 2020 census, the population was 186,847. Its county seat is Punta Gorda.