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Chehalis, Washington

Chehalis is a city in Lewis County, United States. The population was 7,259 at the 2010 census, it is the county seat of Lewis County. Chehalis began as a settlement around a warehouse beside a railroad track in 1873, when the Northern Pacific Railroad built northward from Kalama to Tacoma, ignored Claquato the county seat three miles to the west. After the Northern Pacific bypassed Claquato, the county seat was moved to Chehalis, leaving Claquato little more than a historical landmark. By 1874, a store was added to the warehouse, several houses were constructed; the new town was first named Saundersville, for S. S. Saunders, on whose donation land claim it was founded. In 1879, the name was changed to Chehalis, named after the Chehalis people. Chehalis was incorporated on November 23, 1883. Logging soon began in the nearby forests. Lumber workers of Scandinavian, Anglo-Saxon, Scots-Irish descent arrived and settled in the neighboring valleys. In 1940, the chief local industries were: dairying, poultry raising, fruit growing, milk condensing and vegetable packing and tile manufacturing, coal mining, portable house manufacturing, fern shipping.

According to the U. S. Census Bureau, the city has a total area of 5.55 square miles, of which, 5.53 square miles is land and 0.02 square miles is water. The city straddles Interstate 5 at a point exactly halfway between Seattle and Portland, Oregon; the historic downtown and most of the city's amenities lie on the east side of the freeway, nestled at the base of a small range of forested hills. On the west side of the freeway are parks, farms, a few subdivisions developed in the hills to the west, a centralized shopping district. A small airport is located west of the freeway towards the northern end of the city. From numerous vantage points in the hills just west of town, one can see Mount Rainier, Mount Adams, Mount St. Helens—weather permitting. Chehalis is a frequented stop by bicyclists while on the annual Seattle to Portland Bicycle Classic; the Chehalis River winds its way through the valley in which the city resides, is joined by a tributary, the Newaukum River. This confluence of waters, along with the intersections of tributaries and railroads within Chehalis, helped the city become known as "The Maple Leaf City".

Both the Chehalis and Newaukum rivers are prone to flooding during periods of abnormally heavy or persistent rain, the lowlands from the freeway westward are susceptible to inundation. This region experiences warm and dry summers, with no average monthly temperatures above 71.6 °F. According to the Köppen Climate Classification system, Chehalis has a warm-summer Mediterranean climate, abbreviated "Csb" on climate maps; as of the census of 2010, there were 7,259 people, 2,868 households, 1,655 families residing in the city. The population density was 1,312.7 inhabitants per square mile. There were 3,131 housing units at an average density of 566.2 per square mile. The racial makeup of the city was 87.0% White, 1.7% African American, 1.3% Native American, 1.3% Asian, 0.2% Pacific Islander, 5.7% from other races, 2.8% from two or more races. Hispanic or Latino of any race were 11.6% of the population. There were 2,868 households of which 31.1% had children under the age of 18 living with them, 36.9% were married couples living together, 14.9% had a female householder with no husband present, 6.0% had a male householder with no wife present, 42.3% were non-families.

35.3% of all households were made up of individuals and 16.8% had someone living alone, 65 years of age or older. The average household size was 2.36 and the average family size was 3.02. The median age in the city was 33.5 years. 24.5% of residents were under the age of 18. The gender makeup of the city was 50.2% male and 49.8% female. As of the census of 2000, there were 7,057 people, 2,671 households, 1,696 families residing in the city; the population density was 1,259.0 people per square mile. There were 2,871 housing units at an average density of 512.2 per square mile. The racial makeup of the city was 89.56% White, 1.35% African American, 1.46% Native American, 1.20% Asian, 0.24% Pacific Islander, 3.95% from other races, 2.24% from two or more races. Hispanic or Latino of any race were 7.91% of the population. 18.4 % were of 11.0 % English, 11.0 % American and 8.4 % Irish ancestry. There were 2,671 households out of which 33.2% had children under the age of 18 living with them, 43.8% were married couples living together, 14.4% had a female householder with no husband present, 36.5% were non-families.

30.4% of all households were made up of individuals and 15.1% had someone living alone, 65 years of age or older. The average household size was 2.46 and the average family size was 3.06. In the city, the population was spread out with 29.2% under the age of 18, 11.4% from 18 to 24, 26.6% from 25 to 44, 18.9% from 45 to 64, 14.0% who were 65 years of age or older. The median age was 32 years. For every 100 females, there were 102.0 males. For every 100 females age 18 and over, there were 94.0 males. The median income for a household in the city was $33,482, the median income for a family was $41,387. Males had a median income of $32,289 versus $24,414 for females; the per capita income for the city was $15,944. About 16

Clarence Drive

Clarence Drive is a mountain pass crossed by the R44 road between Gordon's Bay and Rooi-Els. The tourist route is 22 km long and provides a panoramic view of False Bay, the coastline, Table Mountain, parts of the Cape Peninsula; the nearby coast is popular with anglers and whale watchers, Kogel Bay Resort is sought after by surfers. The drive follows the east coast of False Bay in Western Cape, South Africa, connects Strand with Hanglip to the south to Chapman's Peak Drive. In the past, supplies walked up the pass by drovers. Businessman Gerald "Jack" Clarence, who owned property in Hangklip and Betty's Bay, proposed building a road through the area, which would begin construction in 1940 and would be completed by Italian POWs during World War II. On May 29, 1998, Premier of the Western Cape Gerald Morkel opened reconstructed portions of the road. Overlooks have been built; the road begins near Gordon's Bay, winds south over the mouth of the Steenbras River and proceeds past Kogel Bay, Sparks' Bay, Rooi-Els to near Pringle Bay.

Here the pathway forks, with one road going near Cape Hangklip and the other lifting it to Betty's Bay. List of mountain passes in South Africa

Zero instruction set computer

In computer science, zero instruction set computer refers to a computer architecture based on pattern matching and absence of instructions in the classical sense. These chips are known for being thought of as comparable to the neural networks, being marketed for the number of "synapses" and "neurons"; the acronym ZISC alludes to reduced instruction set computer. ZISC is a hardware implementation of Kohonen networks allowing massively parallel processing of simple data; this hardware implementation was invented by Guy Paillet, developed in cooperation with the IBM chip factory of Essonnes, in France, was commercialized by IBM. The ZISC architecture alleviates the memory bottleneck by blending pattern memory with pattern learning and recognition logic, their massively parallel computing solves the "winner takes all problem in action selection" by allotting each "neuron" its own memory and allowing simultaneous problem-solving the results of which are settled up disputing with each other. According to TechCrunch, software emulations of these types of chips are used for image recognition by many large tech companies, such as Facebook and Google.

When applied to other miscellaneous pattern detection tasks, such as with text, results are said to be produced in microseconds with chips released in 2007. Junko Yoshida, of the EE Times, compared the NeuroMem chip with "The Machine", a machine capable of being able to predict crimes from scanning people's faces, from Person of Interest describing it as "the heart of big data" and "foreshadow a real-life escalation in the era of massive data collection". Content-addressable memory One instruction set computer TrueNorth US Patent for ZISC hardware, issued to IBM/G. Paillet on April 15, 1997 Image Processing Using RBF like Neural Networks: A ZISC-036 Based Fully Parallel Implementation Solving Real World and Real Complexity Industrial Problems by K. Madani, G. de Trémiolles, P. Tannhof From CISC to RISC to ZISC by S. Liebman on Neural Networks on Silicon at Zero instruction set computer at Curlie


Lonidamine is a derivative of indazole-3-carboxylic acid, which for a long time, has been known to inhibit aerobic glycolysis in cancer cells. It seems to suppress glycolysis in cancer cells; this is most through the inhibition of the mitochondrially bound hexokinase. Studies in Ehrlich ascites tumor cells showed that lonidamine inhibits both respiration and glycolysis leading to a decrease in cellular ATP. Clinical trials of lonidamine in combination with other anticancer agents for a variety of cancers has begun; this is due to its proven ability to inhibit energy metabolism in cancer cells, to enhance the activity of anticancer agents. Lonidamine has been used in the treatment of brain tumours in combination with radiotherapy and temozolomide. An in-vitro study showed that a combination of temozolomide and lonidamine at clinically achievable, low plasma concentrations, could inhibit tumour growth, lonidamine could reduce the dose of temozolomide required for radiosensitization of brain tumours.

A derivative of lonidamine, gamendazole, is in testing as a possible male contraceptive pill

Yamaha YA-1

The Yamaha YA-1 is the first motorcycle produced by the Yamaha Motor Company. It was made from 1955 to 1958; this was the first vehicle in Japan to have a primary kick start system. The Society of Automotive Engineers of Japan, includes the 1955 Yamaha 125YA-1 as one of their 240 Landmarks of Japanese Automotive Technology. In the early-1950s, Yamaha had to replace its musical instrument factories as they were damaged during the war. Yamaha was facing the industrial conversion of factory machine tools, used during the war for the production of fuel tanks, wing parts, propellers for aircraft of the Imperial Japanese Navy, such as the Mitsubishi A6M Zero fighter; as in European countries, the motorcycle had become a widespread means of transportation in Japan after World War II due to ease of production and economy of purchase and use. Japanese motorcycle production increased from 10,000 units in 1950 to 750,000 in 1954, with over 100 domestic manufacturers. Due to the strong expansion of the market, Yamaha Motor Co. decided to convert to the production of motorcycles, found in the beginning the need to grapple with high specifications, for customers with elite, rather narrow needs in view of the reduced number of production potential.

In January 1955, Nippon Gakki's Hamana Factory in Hamakita was ready to begin production of the YA-1, the first bikes were delivered to dealers in February. This new motorcycle had been influenced by the contemporary DKW model RT125, like the DKW was driven by a 125 cc two-stroke, single cylinder engine, but the YA-1 designers paid particular attention to materials and engineering upgrades, such as going from a three-speed to a four-speed transmission. With confidence in the new direction that Genichi Kawakami was taking, Nippon Gakki founded Yamaha Motor Co. Ltd. on July 1, 1955 and made Kawakami the new company's first president. Staffed by 275 employees, the new motorcycle manufacturer built about 200 units per month by the end of 1955; that same year, Yamaha entered its new YA-1 in the two biggest race events in Japan. They were the 3rd Mt. Fuji Ascent Race held in July 1955, the 1st Asama Highlands Race in November. In these debut races, Yamaha won the 125 cc class; the following year, the YA-1 won again in both the Light and Ultra-light classes of the Asama Highlands Race.

The YA-1 soon established a reputation as a high-quality and reliable machine, which Japanese enthusiasts affectionately nicknamed the Aka-tombo for its slender shape and elegant chestnut red finish. Outstanding race performance had made the YA-1 much more desirable, in spite of its price of ¥138,000 in 1955. Thanks to the popularity of the YA-1, a YB-1 model with a 4 cc larger displacement was produced in 1955. A genuine successor to the YA-1, the 175 cc YC-1 was being produced by April 1956; the YA-1 was the first Japanese motorcycle to take advantage of a primary starting mechanism. Motorcycles with a non-primary starting system used the transmission input shaft and clutch hub to connect the kick-start lever to crankshaft, it was thus necessary for the rider to first put the transmission into neutral, to engage the clutch before the starting the engine by pushing down on the kick-start lever. With its primary starting system, the YA-1 engine is equipped with a mechanism in which the primary driven gear is turned by means of a kick idling gear and kick pinion.

This enables the rider to pull the clutch lever on the handlebar and to kick-start engine, regardless of whether the transmission is in neutral or in gear. This mechanism is now the established kick start system for motorcycles worldwide; the 2011 Tokyo Motor Show included a retrofuturistic concept motorcycle from Yamaha, designed along the lines of the 1955 YA-1. The Y125 Moegi is powered by an air-cooled 125cc single-cylinder engine sitting in an aluminum frame for a claimed weight of just 80 kilograms, which makes the Moegi lighter than the YA-1 was; the Moegi uses a low-maintenance belt final drive and rides on 20-inch wheels. The modified engine is based on the power plant of the YBR125 and Yamaha claims a fuel consumption of 80 km/L for the Y125 Moegi, making it efficient personal transportation in urban environments. List of motorcycles of the 1950s

1991 Canada Cup

The 1991 Labatt Canada Cup was a professional international ice hockey tournament played in August and September 1991. The finals took place in Montreal on September 14 and Hamilton on September 16, were won by Canada; the Canadians defeated the USA in a two-game sweep, to win the final Canada Cup. The tournament was replaced by the World Cup of Hockey in 1996. Of the five Canada Cup tournaments, this is the only one in which a team went undefeated, with two ties. Canada compiled two ties in eight games; the first tie was a stunning 2–2 result with underdog Finland on the opening day of the tournament, who got spectacular goaltending from Markus Ketterer. Finland surprised many by finishing in third place in the round robin; the Americans were very strong, as they iced their best international line-up to date. They went a perfect 5–0 against European competition in the tournament, while losing three times to Canada; the team representing the USSR was weak compared to past tournaments, it did not have many of its top stars due to severe political turmoil at home, many players declining to play for the team, purposely left off the roster for fears of defection.

It was not known until weeks before the start of the tournament that they would send a team. This was the final major senior event. Game 1 of the final is best remembered for the check on Wayne Gretzky by American defenseman Gary Suter, which knocked the Canadian captain out of the tournament and forced him to miss the first month of the NHL season. Game 2 was tied until late in the third period when Steve Larmer scored the tournament winner on a short-handed breakaway. See 1991 Canada Cup rosters Top Goalie: Bill Ranford, Canada Canada Bill Ranford, Goaltender: Bill Ranford, Canada Defence: Al MacInnis, Canada.