Cheltenham Spa railway station serves the spa town of Cheltenham in Gloucestershire, England. Situated on the Bristol-Birmingham main line, it is managed by Great Western Railway, despite most services being operated by CrossCountry which does not manage any stations. It is located about one mile from the town centre. The official name of the town is simply Cheltenham but, when the station was renamed in 1925, the London, Midland and Scottish Railway chose to add Spa to the station name. It is a key regional interchange and is the busiest station in Gloucestershire, as well as one of the busiest railway stations in South West England.

Cheltenham is a spa town and borough on the edge of the Cotswolds in Gloucestershire, England. Cheltenham became known as a health and holiday spa town resort following the discovery of mineral springs in 1716, and claims to be the most complete Regency town in Britain.