1.
Columbus, Ohio
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Columbus is the capital and largest city of the U. S. state of Ohio. It is the 15th-largest city in the United States, with a population of 850,106 as of 2015 estimates and this makes Columbus the fourth-most populous state capital in the United States, and the third-largest city in the Midwestern United States. It is the city of the Columbus, Ohio, Metropolitan Statistical Area. With a population of 2,021,632, it is Ohios third-largest metropolitan area, Columbus is the county seat of Franklin County. The city proper has also expanded and annexed portions of adjoining Delaware County, named for explorer Christopher Columbus, the city was founded in 1812 at the confluence of the Scioto and Olentangy rivers, and assumed the functions of state capital in 1816. As of 2013, the city has the headquarters of five corporations in the U. S, fortune 500, Nationwide Mutual Insurance Company, American Electric Power, L Brands, Big Lots, and Cardinal Health. In 2012, Columbus was ranked in BusinessWeeks 50 best cities in America. In 2013, Forbes gave Columbus an A rating as one of the top cities for business in the U. S. and later that included the city on its list of Best Places for Business. Columbus was also ranked as the No.1 up-and-coming tech city in the nation by Forbes in 2008, and the city was ranked a top-ten city by Relocate America in 2010. In 2007, fDi Magazine ranked the city no.3 in the U. S. for cities of the future, and the Columbus Zoo and Aquarium was rated no.1 in 2009 by USA Travel Guide. The area including modern-day Columbus once comprised the Ohio Country, under the control of the French colonial empire through the Viceroyalty of New France from 1663 until 1763. In the 18th century, European traders flocked to the area, the area found itself frequently caught between warring factions, including American Indian and European interests. In the 1740s, Pennsylvania traders overran the territory until the French forcibly evicted them, in the early 1750s, the Ohio Company sent George Washington to the Ohio Country to survey. Fighting for control of the territory in the French and Indian War became part of the international Seven Years War, during this period, the region routinely suffered turmoil, massacres, and battles. The 1763 Treaty of Paris ceded the Ohio Country to the British Empire, after the American Revolution, the Ohio Country became part of the Virginia Military District, under the control of the United States. Colonists from the East Coast moved in, but rather finding a empty frontier, they encountered people of the Miami, Delaware, Wyandot, Shawnee. The tribes resisted expansion by the fledgling United States, leading to years of bitter conflict, the decisive Battle of Fallen Timbers resulted in the Treaty of Greenville, which finally opened the way for new settlements. By 1797, a surveyor from Virginia named Lucas Sullivant had founded a permanent settlement on the west bank of the forks of the Scioto River
2.
American Chemical Society
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The American Chemical Society is a scientific society based in the United States that supports scientific inquiry in the field of chemistry. Founded in 1876 at New York University, the ACS currently has more than 158,000 members at all levels and in all fields of chemistry, chemical engineering. It is the worlds largest scientific society by membership, the ACS is a 501 non-profit organization and holds a congressional charter under Title 36 of the United States Code. Its headquarters are located in Washington, D. C. and it has a concentration of staff in Columbus. The ACS is a source of scientific information through its peer-reviewed scientific journals, national conferences. Its publications division produces 51 scholarly journals including the prestigious Journal of the American Chemical Society, the ACS holds national meetings twice a year covering the complete field of chemistry and also holds smaller conferences concentrating on specific chemical fields or geographic regions. The primary source of income of the ACS is the Chemical Abstracts Service, the organization also publishes textbooks, administers several national chemistry awards, provides grants for scientific research, and supports various educational and outreach activities. In 1874, a group of American chemists gathered at the Joseph Priestley House to mark the 100th anniversary of Priestleys discovery of oxygen. Two years later, on 6 April 1876, during a meeting of chemists at the University of the City of New York the American Chemical Society was founded, the society received its charter of incorporation from the State of New York in 1877. Charles F. Draper was a photochemist and pioneering photographer who had produced one of the first photographic portraits in 1840, chandler would later serve as president in 1881 and 1889. The Journal of the American Chemical Society was founded in 1879 to publish original chemical research and it was the first journal published by ACS and is still the societys flagship peer-reviewed publication. Chemical & Engineering News is a trade magazine that has been published by ACS since 1923. The society adopted a new constitution aimed at nationalizing the organization in 1890, in 1905, the American Chemical Society moved from New York City to Washington, D. C. ACS was reincorporated under a charter in 1937. It was granted by the U. S. Congress and signed by president Franklin D. Roosevelt, ACSs headquarters moved to its current location in downtown Washington in 1941. Divisional activities include organizing technical sessions at ACS meetings, publishing books and resources, administering awards and lectureships, as of 2016, there are 32 technical divisions of ACS. This is the largest division of the Society and it marked its 100th Anniversary in 2008. The first Chair of the Division was Edward Curtis Franklin, the Organic Division played a part in establishing Organic Syntheses, Inc. and Organic Reactions, Inc. and it maintains close ties to both organizations
3.
United States
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Forty-eight of the fifty states and the federal district are contiguous and located in North America between Canada and Mexico. The state of Alaska is in the northwest corner of North America, bordered by Canada to the east, the state of Hawaii is an archipelago in the mid-Pacific Ocean. The U. S. territories are scattered about the Pacific Ocean, the geography, climate and wildlife of the country are extremely diverse. At 3.8 million square miles and with over 324 million people, the United States is the worlds third- or fourth-largest country by area, third-largest by land area. It is one of the worlds most ethnically diverse and multicultural nations, paleo-Indians migrated from Asia to the North American mainland at least 15,000 years ago. European colonization began in the 16th century, the United States emerged from 13 British colonies along the East Coast. Numerous disputes between Great Britain and the following the Seven Years War led to the American Revolution. On July 4,1776, during the course of the American Revolutionary War, the war ended in 1783 with recognition of the independence of the United States by Great Britain, representing the first successful war of independence against a European power. The current constitution was adopted in 1788, after the Articles of Confederation, the first ten amendments, collectively named the Bill of Rights, were ratified in 1791 and designed to guarantee many fundamental civil liberties. During the second half of the 19th century, the American Civil War led to the end of slavery in the country. By the end of century, the United States extended into the Pacific Ocean. The Spanish–American War and World War I confirmed the status as a global military power. The end of the Cold War and the dissolution of the Soviet Union in 1991 left the United States as the sole superpower. The U. S. is a member of the United Nations, World Bank, International Monetary Fund, Organization of American States. The United States is a developed country, with the worlds largest economy by nominal GDP. It ranks highly in several measures of performance, including average wage, human development, per capita GDP. While the U. S. economy is considered post-industrial, characterized by the dominance of services and knowledge economy, the United States is a prominent political and cultural force internationally, and a leader in scientific research and technological innovations. In 1507, the German cartographer Martin Waldseemüller produced a map on which he named the lands of the Western Hemisphere America after the Italian explorer and cartographer Amerigo Vespucci
4.
Chemistry
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Chemistry is a branch of physical science that studies the composition, structure, properties and change of matter. Chemistry is sometimes called the science because it bridges other natural sciences, including physics. For the differences between chemistry and physics see comparison of chemistry and physics, the history of chemistry can be traced to alchemy, which had been practiced for several millennia in various parts of the world. The word chemistry comes from alchemy, which referred to a set of practices that encompassed elements of chemistry, metallurgy, philosophy, astrology, astronomy, mysticism. An alchemist was called a chemist in popular speech, and later the suffix -ry was added to this to describe the art of the chemist as chemistry, the modern word alchemy in turn is derived from the Arabic word al-kīmīā. In origin, the term is borrowed from the Greek χημία or χημεία and this may have Egyptian origins since al-kīmīā is derived from the Greek χημία, which is in turn derived from the word Chemi or Kimi, which is the ancient name of Egypt in Egyptian. Alternately, al-kīmīā may derive from χημεία, meaning cast together, in retrospect, the definition of chemistry has changed over time, as new discoveries and theories add to the functionality of the science. The term chymistry, in the view of noted scientist Robert Boyle in 1661, in 1837, Jean-Baptiste Dumas considered the word chemistry to refer to the science concerned with the laws and effects of molecular forces. More recently, in 1998, Professor Raymond Chang broadened the definition of chemistry to mean the study of matter, early civilizations, such as the Egyptians Babylonians, Indians amassed practical knowledge concerning the arts of metallurgy, pottery and dyes, but didnt develop a systematic theory. Greek atomism dates back to 440 BC, arising in works by such as Democritus and Epicurus. In 50 BC, the Roman philosopher Lucretius expanded upon the theory in his book De rerum natura, unlike modern concepts of science, Greek atomism was purely philosophical in nature, with little concern for empirical observations and no concern for chemical experiments. Work, particularly the development of distillation, continued in the early Byzantine period with the most famous practitioner being the 4th century Greek-Egyptian Zosimos of Panopolis. He formulated Boyles law, rejected the four elements and proposed a mechanistic alternative of atoms. Before his work, though, many important discoveries had been made, the Scottish chemist Joseph Black and the Dutchman J. B. English scientist John Dalton proposed the theory of atoms, that all substances are composed of indivisible atoms of matter. Davy discovered nine new elements including the alkali metals by extracting them from their oxides with electric current, british William Prout first proposed ordering all the elements by their atomic weight as all atoms had a weight that was an exact multiple of the atomic weight of hydrogen. The inert gases, later called the noble gases were discovered by William Ramsay in collaboration with Lord Rayleigh at the end of the century, thereby filling in the basic structure of the table. Organic chemistry was developed by Justus von Liebig and others, following Friedrich Wöhlers synthesis of urea which proved that organisms were, in theory
5.
International Standard Serial Number
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An International Standard Serial Number is an eight-digit serial number used to uniquely identify a serial publication. The ISSN is especially helpful in distinguishing between serials with the same title, ISSN are used in ordering, cataloging, interlibrary loans, and other practices in connection with serial literature. The ISSN system was first drafted as an International Organization for Standardization international standard in 1971, ISO subcommittee TC 46/SC9 is responsible for maintaining the standard. When a serial with the content is published in more than one media type. For example, many serials are published both in print and electronic media, the ISSN system refers to these types as print ISSN and electronic ISSN, respectively. The format of the ISSN is an eight digit code, divided by a hyphen into two four-digit numbers, as an integer number, it can be represented by the first seven digits. The last code digit, which may be 0-9 or an X, is a check digit. Formally, the form of the ISSN code can be expressed as follows, NNNN-NNNC where N is in the set, a digit character. The ISSN of the journal Hearing Research, for example, is 0378-5955, where the final 5 is the check digit, for calculations, an upper case X in the check digit position indicates a check digit of 10. To confirm the check digit, calculate the sum of all eight digits of the ISSN multiplied by its position in the number, the modulus 11 of the sum must be 0. There is an online ISSN checker that can validate an ISSN, ISSN codes are assigned by a network of ISSN National Centres, usually located at national libraries and coordinated by the ISSN International Centre based in Paris. The International Centre is an organization created in 1974 through an agreement between UNESCO and the French government. The International Centre maintains a database of all ISSNs assigned worldwide, at the end of 2016, the ISSN Register contained records for 1,943,572 items. ISSN and ISBN codes are similar in concept, where ISBNs are assigned to individual books, an ISBN might be assigned for particular issues of a serial, in addition to the ISSN code for the serial as a whole. An ISSN, unlike the ISBN code, is an identifier associated with a serial title. For this reason a new ISSN is assigned to a serial each time it undergoes a major title change, separate ISSNs are needed for serials in different media. Thus, the print and electronic versions of a serial need separate ISSNs. Also, a CD-ROM version and a web version of a serial require different ISSNs since two different media are involved, however, the same ISSN can be used for different file formats of the same online serial
6.
OCLC
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The Online Computer Library Center is a US-based nonprofit cooperative organization dedicated to the public purposes of furthering access to the worlds information and reducing information costs. It was founded in 1967 as the Ohio College Library Center, OCLC and its member libraries cooperatively produce and maintain WorldCat, the largest online public access catalog in the world. OCLC is funded mainly by the fees that libraries have to pay for its services, the group first met on July 5,1967 on the campus of the Ohio State University to sign the articles of incorporation for the nonprofit organization. The group hired Frederick G. Kilgour, a former Yale University medical school librarian, Kilgour wished to merge the latest information storage and retrieval system of the time, the computer, with the oldest, the library. The goal of network and database was to bring libraries together to cooperatively keep track of the worlds information in order to best serve researchers and scholars. The first library to do online cataloging through OCLC was the Alden Library at Ohio University on August 26,1971 and this was the first occurrence of online cataloging by any library worldwide. Membership in OCLC is based on use of services and contribution of data, between 1967 and 1977, OCLC membership was limited to institutions in Ohio, but in 1978, a new governance structure was established that allowed institutions from other states to join. In 2002, the structure was again modified to accommodate participation from outside the United States. As OCLC expanded services in the United States outside of Ohio, it relied on establishing strategic partnerships with networks, organizations that provided training, support, by 2008, there were 15 independent United States regional service providers. OCLC networks played a key role in OCLC governance, with networks electing delegates to serve on OCLC Members Council, in early 2009, OCLC negotiated new contracts with the former networks and opened a centralized support center. OCLC provides bibliographic, abstract and full-text information to anyone, OCLC and its member libraries cooperatively produce and maintain WorldCat—the OCLC Online Union Catalog, the largest online public access catalog in the world. WorldCat has holding records from public and private libraries worldwide. org, in October 2005, the OCLC technical staff began a wiki project, WikiD, allowing readers to add commentary and structured-field information associated with any WorldCat record. The Online Computer Library Center acquired the trademark and copyrights associated with the Dewey Decimal Classification System when it bought Forest Press in 1988, a browser for books with their Dewey Decimal Classifications was available until July 2013, it was replaced by the Classify Service. S. The reference management service QuestionPoint provides libraries with tools to communicate with users and this around-the-clock reference service is provided by a cooperative of participating global libraries. OCLC has produced cards for members since 1971 with its shared online catalog. OCLC commercially sells software, e. g. CONTENTdm for managing digital collections, OCLC has been conducting research for the library community for more than 30 years. In accordance with its mission, OCLC makes its research outcomes known through various publications and these publications, including journal articles, reports, newsletters, and presentations, are available through the organizations website. The most recent publications are displayed first, and all archived resources, membership Reports – A number of significant reports on topics ranging from virtual reference in libraries to perceptions about library funding
7.
Academic journal
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An academic or scholarly journal is a periodical publication in which scholarship relating to a particular academic discipline is published. Academic journals serve as permanent and transparent forums for the presentation, scrutiny and they are usually peer-reviewed or refereed. Content typically takes the form of articles presenting original research, review articles, the term academic journal applies to scholarly publications in all fields, this article discusses the aspects common to all academic field journals. Upon receipt of an article, editors at the journal determine whether to reject the submission outright or begin the process of peer review. In the latter case, the submission becomes subject to review by scholars of the editors choosing who typically remain anonymous. Though these reports are confidential, some journals and publishers also practice public peer review. The editors either choose to reject the article, ask for a revision and resubmission, even accepted articles are often subjected to further editing by journal editorial staff before they appear in print. The peer review can take several weeks to several months. Review articles, also called reviews of progress, are checks on the published in journals. Some journals are devoted entirely to review articles, some contain a few in each issue, such reviews often cover the research from the preceding year, some for longer or shorter terms, some are devoted to specific topics, some to general surveys. Some journals are enumerative, listing all significant articles in a subject, others are selective. Yet others are evaluative, judging the state of progress in the subject field, some journals are published in series, each covering a complete subject field year, or covering specific fields through several years. Unlike original research articles, review articles tend to be solicited submissions and they are typically relied upon by students beginning a study in a given field, or for current awareness of those already in the field. Reviews of scholarly books are checks upon the books published by scholars, unlike articles. Journals typically have a book review editor determining which new books to review. If an outside scholar accepts the book review editors request for a book review, publishers send books to book review editors in the hope that their books will be reviewed. The length and depth of research book reviews varies much from journal to journal, as does the extent of textbook, an academic journals prestige is established over time, and can reflect many factors, some but not all of which are expressible quantitatively. In each academic discipline there are dominant journals that receive the largest number of submissions, yet, not only the largest journals are of excellent quality
8.
Thesis
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A thesis or dissertation is a document submitted in support of candidature for an academic degree or professional qualification presenting the authors research and findings. In some contexts, the thesis or a cognate is used for part of a bachelors or masters course, while dissertation is normally applied to a doctorate, while in other contexts. The term graduate thesis is used to refer to both masters theses and doctoral dissertations. The required complexity or quality of research of a thesis or dissertation can vary by country, university, or program, the word dissertation can at times be used to describe a treatise without relation to obtaining an academic degree. The term thesis is used to refer to the general claim of an essay or similar work. The term thesis comes from the Greek θέσις, meaning something put forth, Dissertation comes from the Latin dissertātiō, meaning path. A thesis may be arranged as a thesis by publication or a monograph, with or without appended papers, an ordinary monograph has a title page, an abstract, a table of contents, comprising the various chapters, and a bibliography or a references section. They differ in their structure in accordance with the different areas of study. In a thesis by publication, the chapters constitute an introductory, Dissertations normally report on a research project or study, or an extended analysis of a topic. The structure of the thesis or dissertation explains the purpose, the research literature which impinges on the topic of the study, the methods used. Degree-awarding institutions often define their own style that candidates have to follow when preparing a thesis document. Other applicable international standards include ISO2145 on section numbers, ISO690 on bibliographic references, some older house styles specify that front matter uses a separate page-number sequence from the main text, using Roman numerals. They therefore avoid the traditional separate number sequence for front matter, however, strict standards are not always required. Most Italian universities, for example, have only general requirements on the size and the page formatting. A thesis or dissertation committee is a committee that supervises a students dissertation, the committee members are doctors in their field and have the task of reading the dissertation, making suggestions for changes and improvements, and sitting in on the defense. Sometimes, at least one member of the committee must be a professor in a department that is different from that of the student, all the dissertation referees must already have achieved at least the academic degree that the candidate is trying to reach. At English-speaking Canadian universities, writings presented in fulfillment of undergraduate coursework requirements are normally called papers, a longer paper or essay presented for completion of a 4-year bachelors degree is sometimes called a major paper. High-quality research papers presented as the study of a postgraduate consecutive bachelor with Honours or Baccalaureatus Cum Honore degree are called thesis
9.
Book
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A book is a set of written, printed, illustrated, or blank sheets, made of paper, parchment, or other materials, fastened together to hinge at one side, with text and/or images printed in ink. A single sheet within a book is a leaf, and each side of a leaf is a page, a set of text-filled or illustrated pages produced in electronic format for reading on a computer screen, smartphone or e-reader device is known as an electronic book, or e-book. The term books may refer the body of works of literature. In library and information science, a book is called a monograph, to distinguish it from serial periodicals such as magazines, journals, in novels and sometimes other types of books, a book may be divided into several large sections, also called books. An avid reader or collector of books or a lover is a bibliophile or colloquially. A shop where books are bought and sold is a bookshop or bookstore, Books are also sold in some department stores, drugstores and newspaper vendors. Books can also be borrowed from libraries, google has estimated that as of 2010, approximately 130,000,000 distinct titles had been published. In some wealthier nations, printed books are giving way to the usage of electronic or e-books, the word book comes from Old English bōc, which in turn comes from the Germanic root *bōk-, cognate to beech. Similarly, in Slavic languages буква is cognate with beech, in Russian and in Serbian and Macedonian, the word букварь or буквар refers specifically to a primary school textbook that helps young children master the techniques of reading and writing. It is thus conjectured that the earliest Indo-European writings may have been carved on beech wood, similarly, the Latin word codex, meaning a book in the modern sense, originally meant block of wood. When writing systems were created in ancient civilizations, a variety of objects, such as stone, clay, tree bark, metal sheets, the study of such inscriptions forms a major part of history. The study of inscriptions is known as epigraphy, the Ancient Egyptians would often write on papyrus, a plant grown along the Nile River. At first the words were not separated from other and there was no punctuation. Texts were written right to left, left to right. The technical term for that last type of writing is boustrophedon, a tablet might be defined as a physically robust writing medium, suitable for casual transport and writing. See also stylus, the instrument used to write on a tablet, clay tablets were flattened and mostly dry pieces of clay that could be easily carried, and impressed with a stylus. They were used as a medium, especially for writing in cuneiform, throughout the Bronze Age. Tablets were used by traders to record sales of such as bushels of grain
10.
Patent
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A patent is a set of exclusive rights granted by a sovereign state to an inventor or assignee for a limited period of time in exchange for detailed public disclosure of an invention. An invention is a solution to a technological problem and is a product or a process. Patents are a form of intellectual property, the procedure for granting patents, requirements placed on the patentee, and the extent of the exclusive rights vary widely between countries according to national laws and international agreements. Typically, however, a patent application must include one or more claims that define the invention. A patent may include many claims, each of which defines a specific property right and these claims must meet relevant patentability requirements, such as novelty, usefulness, and non-obviousness. Nevertheless, there are variations on what is patentable subject matter from country to country, the word patent originates from the Latin patere, which means to lay open. More directly, it is a version of the term letters patent. Similar grants included land patents, which were land grants by early state governments in the USA, and printing patents, a precursor of modern copyright. In modern usage, the term patent usually refers to the granted to anyone who invents any new, useful. The additional qualification utility patent is used to distinguish the primary meaning from these other types of patents. Particular species of patents for inventions include biological patents, business method patents, chemical patents, the period of protection was 10 years. These were mostly in the field of glass making, as Venetians emigrated, they sought similar patent protection in their new homes. This led to the diffusion of patent systems to other countries, by the 16th century, the English Crown would habitually abuse the granting of letters patent for monopolies. After public outcry, King James I of England was forced to revoke all existing monopolies, the Statute became the foundation for later developments in patent law in England and elsewhere. Important developments in patent law emerged during the 18th century through a process of judicial interpretation of the law. During the reign of Queen Anne, patent applications were required to supply a complete specification of the principles of operation of the invention for public access. Influenced by the philosophy of John Locke, the granting of patents began to be viewed as a form of property right. The English legal system became the foundation for patent law in countries with a common law heritage, including the United States, New Zealand, in the Thirteen Colonies, inventors could obtain patents through petition to a given colonys legislature
11.
Nucleic acid sequence
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A nucleic acid sequence is a succession of letters that indicate the order of nucleotides within a DNA or RNA molecule. By convention, sequences are presented from the 5 end to the 3 end. For DNA, the strand is used. Because nucleic acids are linear polymers, specifying the sequence is equivalent to defining the covalent structure of the entire molecule. For this reason, the nucleic acid sequence is also termed the primary structure, the sequence has capacity to represent information. Biological deoxyribonucleic acid represents the information which directs the functions of a living thing, nucleic acids also have a secondary structure and tertiary structure. Primary structure is sometimes referred to as primary sequence. Conversely, there is no concept of secondary or tertiary sequence. Nucleic acids consist of a chain of linked units called nucleotides, each nucleotide consists of three subunits, a phosphate group and a sugar make up the backbone of the nucleic acid strand, and attached to the sugar is one of a set of nucleobases. The nucleobases are important in base pairing of strands to form secondary and tertiary structure such as the famed double helix. The possible letters are A, C, G, and T, in the typical case, the sequences are printed abutting one another without gaps, as in the sequence AAAGTCTGAC, read left to right in the 5 to 3 direction. With regards to transcription, a sequence is on the strand if it has the same order as the transcribed RNA. One sequence can be complementary to sequence, meaning that they have the base on each position in the complementary. For example, the sequence to TTAC is GTAA. If one strand of the double-stranded DNA is considered the sense strand, then the other strand, considered the antisense strand, will have the complementary sequence to the sense strand. Apart from adenine, cytosine, guanine, thymine and uracil, in DNA, the most common modified base is 5-methylcytidine. In RNA, there are many modified bases, including pseudouridine, dihydrouridine, inosine, ribothymidine and 7-methylguanosine, hypoxanthine and xanthine are two of the many bases created through mutagen presence, both of them through deamination. Hypoxanthine is produced from adenine, xanthine from guanine, similarly, deamination of cytosine results in uracil
12.
GenBank
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The GenBank sequence database is an open access, annotated collection of all publicly available nucleotide sequences and their protein translations. This database is produced and maintained by the National Center for Biotechnology Information as part of the International Nucleotide Sequence Database Collaboration, the National Center for Biotechnology Information is a part of the National Institutes of Health in the United States. GenBank and its collaborators receive sequences produced in laboratories throughout the world more than 100,000 distinct organisms. GenBank continues to grow at a rate, doubling every 18 months. Release 194, produced in February 2013, contained over 150 billion nucleotide bases in more than 162 million sequences, GenBank is built by direct submissions from individual laboratories, as well as from bulk submissions from large-scale sequencing centers. Only original sequences can be submitted to GenBank, direct submissions are made to GenBank using BankIt, which is a Web-based form, or the stand-alone submission program, Sequin. Upon receipt of a submission, the GenBank staff examines the originality of the data and assigns an accession number to the sequence. The submissions are then released to the database, where the entries are retrievable by Entrez or downloadable by FTP. Bulk submissions of Expressed Sequence Tag, Sequence-tagged site, Genome Survey Sequence, the GenBank direct submissions group also processes complete microbial genome sequences. Funding was provided by the National Institutes of Health, the National Science Foundation, the Department of Energy, LANL collaborated on GenBank with the firm Bolt, Beranek, and Newman, and by the end of 1983 more than 2,000 sequences were stored in it. In the mid 1980s, the Intelligenetics bioinformatics company at Stanford University managed the GenBank project in collaboration with LANL, as one of the earliest bioinformatics community projects on the Internet, the GenBank project started BIOSCI/Bionet news groups for promoting open access communications among bioscientists. During 1989 to 1992, the GenBank project transitioned to the newly created National Center for Biotechnology Information, the GenBank release notes for release 162.0 state that from 1982 to the present, the number of bases in GenBank has doubled approximately every 18 months. As of 15 June 2016, GenBank release 214.0 has 194,463,572 loci,213,200,907,819 bases, from 194,463,572 reported sequences. The GenBank database includes data sets that are constructed mechanically from the main sequence data collection. On the other hand, while commercial databases potentially contain high-quality filtered sequence data, the results showed that analyses performed using GenBank combined with EzTaxon-e were more discriminative than using GenBank or other databases alone. GenBank Example sequence record, for hemoglobin beta BankIt Sequin — a stand-alone software tool developed by the NCBI for submitting and updating entries to the GenBank sequence database. EMBOSS — free, open source software for molecular biology GenBank, RefSeq, TPA and UniProt, Whats in a Name
13.
National Institutes of Health
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The National Institutes of Health is a biomedical research facility primarily located in Bethesda, Maryland. An agency of the United States Department of Health and Human Services, it is the agency of the United States government responsible for biomedical. The NIH comprises 27 separate institutes and centers that conduct research in different disciplines of biomedical science, NIHs roots extend back to a Marine Hospital Service in the late 1790s that provided medical relief to sick and disabled men in the U. S. Navy. By 1870, a network of hospitals had developed and was placed under the charge of a medical officer within the Bureau of the Treasury Department. In 1887 a laboratory for the study of bacteria, the Hygienic Laboratory, was established at the Marine Hospital in New York, in the early 1900s, Congress began appropriating funds for the Marine Hospital Service. By 1922, this changed its name to Public Health Services. This marked the beginning of a partnership with universities, in 1930, the Hygienic Laboratory was re-designated as the National Institute of Health by the Ransdell Act and was given $750,000 to construct two NIH buildings. Over the next few decades, Congress would increase its funding tremendously to the NIH, in 1944, the Public Health Service Act was approved, and National Cancer Institute became a division of NIH. In 1948, the changed from National Institute of Health to National Institutes of Health. In the 1960s prominent virologist and cancer researcher Chester M. Southam injected HeLa cancer cells into patients at the Jewish Chronic Disease Hospital, when three doctors resigned after refusing to inject patients without their consent, this experiment gained considerable media attention. The NIH was a source of funding for Southam’s research and had required all research involving human subjects to obtain their consent prior to any experimentation. }Upon investigating all of their grantee institutions. From then on, the NIH has required all grantee institutions to approve any research involving human experimentation with review boards. In 1967 the Division of Regional Medical Programs was created to administer grants for research for heart disease, cancer, and strokes. That same year, the NIH director lobbied the White House for increased funding in order to increase research. An advisory committee was formed to further development of the NIH. The funding of NIH has often been a source of contention in Congress and this contention was seen most dramatically during the 1980s, when President Reagan repeatedly tried to cut funding for research, only to see Congress partly restore funding. But it was not until July 1987, as NIH celebrated its 100th anniversary, by the 1990s, the focus of the NIH committee had shifted to DNA research, and the Human Genome Project was launched. In 2009, President Obama reinstated federally funded research, revoking the ban imposed by President Bush in 2001
14.
IUPAC
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The International Union of Pure and Applied Chemistry /ˈaɪjuːpæk/ or /ˈjuːpæk/ is an international federation of National Adhering Organizations that represents chemists in individual countries. It is a member of the International Council for Science, IUPAC is registered in Zürich, Switzerland, and the administrative office, known as the IUPAC Secretariat, is in Research Triangle Park, North Carolina, United States. This administrative office is headed by IUPACs executive director, currently Lynn Soby, IUPAC was established in 1919 as the successor of the International Congress of Applied Chemistry for the advancement of chemistry. Its members, the National Adhering Organizations, can be national chemistry societies, national academies of sciences, there are fifty-four National Adhering Organizations and three Associate National Adhering Organizations. IUPACs Inter-divisional Committee on Nomenclature and Symbols is the world authority in developing standards for the naming of the chemical elements. Since its creation, IUPAC has been run by different committees with different responsibilities. These committees run different projects which include standardizing nomenclature, finding ways to bring chemistry to the world, IUPAC is best known for its works standardizing nomenclature in chemistry and other fields of science, but IUPAC has publications in many fields including chemistry, biology and physics. IUPAC is also known for standardizing the atomic weights of the elements through one of its oldest standing committees, the need for an international standard for chemistry was first addressed in 1860 by a committee headed by German scientist Friedrich August Kekulé von Stradonitz. This committee was the first international conference to create an international naming system for organic compounds, the ideas that were formulated in that conference evolved into the official IUPAC nomenclature of organic chemistry. IUPAC stands as a legacy of this meeting, making it one of the most important historical international collaborations of chemistry societies, since this time, IUPAC has been the official organization held with the responsibility of updating and maintaining official organic nomenclature. IUPAC as such was established in 1919, one notable country excluded from this early IUPAC is Germany. Germanys exclusion was a result of prejudice towards Germans by the Allied powers after World War I, Germany was finally admitted into IUPAC during 1929. However, Nazi Germany was removed from IUPAC during World War II, during World War II, IUPAC was affiliated with the Allied powers, but had little involvement during the war effort itself. After the war, East and West Germany were eventually readmitted to IUPAC, since World War II, IUPAC has been focused on standardizing nomenclature and methods in science without interruption. In 2016, IUPAC denounced the use of chlorine as a chemical weapon, the letter stated, Our organizations deplore the use of chlorine in this manner. According to the CWC, the use, stockpiling, distribution, IUPAC is governed by several committees that all have different responsibilities. Each committee is made up of members of different National Adhering Organizations from different countries, the steering committee hierarchy for IUPAC is as follows, All committees have an allotted budget to which they must adhere. Any committee may start a project, if a projects spending becomes too much for a committee to continue funding, it must take the issue to the Project Committee
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Client (computing)
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A client is a piece of computer hardware or software that accesses a service made available by a server. The server is often on another system, in which case the client accesses the service by way of a network. The term applies to the role that programs or devices play in the client–server model, a client is a computer program that, as part of its operation, relies on sending a request to another computer program. For example, web browsers are clients that connect to web servers, email clients retrieve email from mail servers. Online chat uses a variety of clients, which depending on the chat protocol being used. Multiplayer video games or online video games may run as a client on each computer, the term client may also be applied to computers or devices that run the client software or users that use the client software. A client is part of a model, which is still used today. Clients and servers may be computer programs run on the same machine, combined with Internet sockets, programs may connect to a service operating on a possibly remote system through the Internet protocol suite. Servers wait for clients to initiate connections that they may accept. The term was first applied to devices that were not capable of running their own stand-alone programs and these dumb terminals were clients of the time-sharing mainframe computer. In one classification, client computers and devices are either fat clients, thin clients, or hybrid clients. A fat client, also known as a client or thick client, is a client that performs the bulk of any data processing operations itself. The personal computer is an example of a fat client, because of its relatively large set of features and capabilities. For example, a running a CAD program that ultimately shares the result of its work on a network is a fat client. A thin client is a sort of client. Thin clients use the resources of the host computer, a thin client generally only presents processed data provided by an application server, which performs the bulk of any required data processing. A device using web application is a thin client, a hybrid client is a mixture of the above two client models. Similar to a fat client, it processes locally, but relies on the server for storing persistent data and this approach offers features from both the fat client and the thin client
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Scientific journal
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In academic publishing, a scientific journal is a periodical publication intended to further the progress of science, usually by reporting new research. There are thousands of journals in publication, and many more have been published at various points in the past. Most journals are highly specialized, although some of the oldest journals such as Nature publish articles, Scientific journals contain articles that have been peer reviewed, in an attempt to ensure that articles meet the journals standards of quality, and scientific validity. If the journals editor considers the paper appropriate, at least two researchers preferably from the same field check the paper for soundness of its scientific argument, although scientific journals are superficially similar to professional magazines, they are actually quite different. Issues of a scientific journal are rarely read casually, as one would read a magazine, the publication of the results of research is an essential part of the scientific method. If they are describing experiments or calculations, they must supply enough details that an independent researcher could repeat the experiment or calculation to verify the results, each such journal article becomes part of the permanent scientific record. Over a thousand, mostly ephemeral, were founded in the 18th century, articles in scientific journals can be used in research and higher education. Scientific articles allow researchers to keep up to date with the developments of their field, an essential part of a scientific article is citation of earlier work. The impact of articles and journals is often assessed by counting citations, some classes are partially devoted to the explication of classic articles, and seminar classes can consist of the presentation by each student of a classic or current paper. Schoolbooks and textbooks have been written only on established topics, while the latest research. In a scientific research group or academic department it is usual for the content of current scientific journals to be discussed in journal clubs, the standards that a journal uses to determine publication can vary widely. Some journals, such as Nature, Science, PNAS, and it is also common for journals to have a regional focus, specializing in publishing papers from a particular country or other geographic region, like African Invertebrates. Articles tend to be technical, representing the latest theoretical research. They are often incomprehensible to anyone except for researchers in the field, in some subjects this is inevitable given the nature of the content. Usually, rigorous rules of writing are enforced by the editors, however. Articles are usually either original articles reporting new results or reviews of current literature. There are also publications that bridge the gap between articles and books by publishing thematic volumes of chapters from different authors. Research notes are short descriptions of current research findings that are considered less urgent or important than Letters, supplemental articles contain a large volume of tabular data that is the result of current research and may be dozens or hundreds of pages with mostly numerical data
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Ohio State University
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The Ohio State University, commonly referred to as Ohio State or OSU, is a large, primarily residential, public university in Columbus, Ohio. Founded in 1870 as a land-grant university and ninth university in Ohio with the Morrill Act of 1862, Hayes, and in 1878 the Ohio General Assembly passed a law changing the name to The Ohio State University. It has since grown into the third-largest university campus in the United States, along with its main campus in Columbus, Ohio State also operates a regional campus system with regional campuses in Lima, Mansfield, Marion, Newark, and Wooster. Ohio State athletic teams compete in Division I of the NCAA and are known as the Ohio State Buckeyes, athletes from Ohio State have won 100 Olympic medals. The university is a member of the Big Ten Conference for the majority of sports, the Ohio State mens ice hockey program competes in the Big Ten Conference, while its womens hockey program competes in the Western Collegiate Hockey Association. In addition, the OSU mens volleyball team is a member of the Midwestern Intercollegiate Volleyball Association, OSU is one of only 14 universities that plays Division I FBS football and Division I ice hockey. As of August 2015, the university had awarded a total of 714,512 degrees, alumni and former students have gone on to prominent careers in government, business, science, medicine, education, sports, and entertainment. Championed by the Republican stalwart Governor Rutherford B, Hayes, the Ohio State University was founded in 1870 as a land-grant university under the Morrill Act of 1862 as the Ohio Agricultural and Mechanical College. The school was originally within a community on the northern edge of Columbus. The university opened its doors to 24 students on September 17,1873, in 1878, the first class of six men graduated. The first woman graduated the following year, also in 1878, in light of its expanded focus, the Ohio legislature changed the name to the now-familiar The Ohio State University, with The as part of its official name. Ohio State began accepting students in the 1880s, and in 1891. It would later acquire colleges of medicine, dentistry, optometry, veterinary medicine, commerce, in 1916, Ohio State was elected into membership in the Association of American Universities. Michael V. Drake, former chancellor of the University of California, Irvine, in an attack against the campus on November 28,2016, an unrelated fluorine leak was called in for Watts Hall, resulting in the evacuation of the building to an outside courtyard. As firetrucks began to depart, Abdul Razak Ali Artan drove into the crowd, then emerged, the attack was stopped in under two minutes by OSU Police Officer Alan Horujko, who witnessed the attack after responding to the reported gas leak, and who shot and killed Artan. The universitys Buckeye Alert system was triggered and the campus was placed on lockdown, Ten were transported to local hospitals and one suspect was killed according to multiple sources. Local law enforcement and the FBI launched an investigation, according to authorities, Artan was inspired by terrorist propaganda from the Islamic State and radical Muslim cleric Anwar al-Awlaki. Ohio States 1, 764-acre main campus is about 2.5 miles north of the citys downtown, the historical center of campus is the Oval, quad of about 11 acres
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Olentangy River
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The Olentangy River /oʊlənˈtændʒi/ is a 97-mile-long tributary of the Scioto River in Ohio. It was originally called keenhongsheconsepung, a Delaware word literally translated as stone for your knife stream, early settlers to the region translated this into Whetstone River. The Delaware State Park Reservoir, also known as Delaware Lake, was constructed along the Olentangy River in 1951, the reservoir is located 5 miles north of the city of Delaware, and was built by the U. S. Army Corps of Engineers for flood control purposes. On January 13,2005, Delaware Dam was nearly overtopped, the water level came within less than 1 foot of the top of the dam, requiring the main spill gates to be opened before it began dropping. The Olentangy River is the source of drinking water for much of Delaware County. Both the City of Delaware and Del-Co Water Company, the supplier of drinking water to most of rural Delaware County, twenty-two miles of the Olentangy have been designated a State Scenic River by the Ohio Department of Natural Resources, Division of Natural Areas & Preserves. The Olentangy River has also known as Keenhongsheconsepung, Oleutangy, Whetstone Creek, Whetstone River. In 2012 the Ohio EPA and the City of Columbus began to some of the lowhead dams that cross the river. Work started with removing the 5th Avenue Dam, the river is now about half of its former width. Work continues to restore the banks and clean the area, list of rivers of Ohio Friends of the Lower Olentangy Watershed Delaware Dam level and outflow graph Olentangy River Level Gauge at Worthington, OH
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Columbus Symphony Orchestra
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The Columbus Symphony Orchestra is an American symphony orchestra based in Columbus, Ohio. The oldest performing arts organization in the city, its home is the Ohio Theatre, the orchestras current President and Chief Creative Officer is Roland Valliere. Rossen Milanov is the music director. The Columbus Symphony offers 14 classical concert programs, mostly in pairs of two performances, and 9 pops programs, in the summer the orchestra performs a series of outdoor pops programs, Picnic with the Pops, on the lawn of Columbus Commons. The Columbus Symphony also serves as the orchestra for Opera Columbus, the Columbus Symphony Orchestra was founded in 1951 as the Columbus Little Symphony, following the demise of the citys previous professional symphony, the Columbus Philharmonic Orchestra. The first music director of the orchestra was the flutist and conductor Claude Monteux, in its first year, the Columbus Little Symphony presented a series of 5 concerts with 28 musicians. Its first full season of concerts took place at Central High School in 1952, in 1955, the Columbus Little Symphony officially became the Columbus Symphony Orchestra. From its founding until 1961, the Symphony was unique in that it was governed exclusively by women, the longest-serving music director was Evan Whallon, who led the orchestra for 26 seasons, from 1956 to 1982. From 1956 to 1970 the orchestra performed concerts at the Franklin County Veterans Memorial Auditorium, the Ohio Theatre has been the orchestras home since 1970. The former movie theater was saved from demolition and renovated largely to provide a new hall for the orchestra, in the absence of a professional opera company in Columbus, the Columbus Symphony began presenting opera in the 1970s. At this time it was able to hire its first full-time musicians. By 1980, the Columbus Symphony was presenting three fully staged operatic productions each year,1983 began the inaugural season of the Columbus Symphony’s Picnic with the Pops summer concert series, now a central Ohio tradition. In addition it began performing with Opera Columbus and Ballet Met and expanded its educational activities, in 2001 it celebrated its 50th anniversary with a debut concert at Carnegie Hall under music director Alessandro Siciliani. Gunther Herbig, the conductor of the Detroit Symphony Orchestra, was the orchestras music adviser during the search for a music director following the tenure of Siciliani. After a two-year search, Junichi Hirokami was named the sixth music director on June 1,2006. The summer pops season was canceled and the orchestras musicians staged a series of independent concerts during the suspension of activities. During the orchestras 2008 financial crisis, Hirokami strongly supported the musicians, on November 13,2008, in a letter to the orchestras musicians, Hirokami announced that the board of the Columbus Symphony Orchestra had dismissed him from his post, effective immediately. Herbig returned as the de facto principal guest conductor, though without that formal title
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United States Environmental Protection Agency
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The EPA was proposed by President Richard Nixon and began operation on December 2,1970, after Nixon signed an executive order. The order establishing the EPA was ratified by committee hearings in the House, the agency is led by its Administrator, who is appointed by the president and approved by Congress. The current administrator is Scott Pruitt, the EPA is not a Cabinet department, but the administrator is normally given cabinet rank. The EPA has its headquarters in Washington, D. C. regional offices for each of the ten regions. The agency conducts environmental assessment, research, and education and it has the responsibility of maintaining and enforcing national standards under a variety of environmental laws, in consultation with state, tribal, and local governments. It delegates some permitting, monitoring, and enforcement responsibility to U. S. states, EPA enforcement powers include fines, sanctions, and other measures. The agency also works with industries and all levels of government in a variety of voluntary pollution prevention programs. In 2016, the agency had 15,376 full-time employees, more than half of EPAs employees are engineers, scientists, and environmental protection specialists, other employees include legal, public affairs, financial, and information technologists. Beginning in the late 1950s and through the 1960s, Congress reacted to increasing concern about the impact that human activity could have on the environment. Senator James E. Murray introduced a bill, the Resources and Conservation Act of 1959, the 1962 publication of Silent Spring by Rachel Carson alerted the public about the detrimental effects on the environment of the indiscriminate use of pesticides. In the years following, similar bills were introduced and hearings were held to discuss the state of the environment, in the colloquium, some members of Congress expressed a continuing concern over federal agency actions affecting the environment. The National Environmental Policy Act of 1969 was modeled on RCA, President Nixon signed NEPA into law on January 1,1970. The law created the Council on Environmental Quality in the Executive Office of the President, NEPA required that a detailed statement of environmental impacts be prepared for all major federal actions significantly affecting the environment. The detailed statement would ultimately be referred to as an impact statement. On July 9,1970, Nixon proposed a reorganization that consolidated many environmental responsibilities of the federal government under one agency. After conducting hearings during that summer, the House and Senate approved the proposal, the agency’s first administrator, William Ruckelshaus, took the oath of office on December 4,1970. In May 2013, Congress renamed the EPA headquarters as the William Jefferson Clinton Federal Building, the EPA is led by an Administrator of the Environmental Protection Agency. As of 2017 Scott Pruitt is the 14th administrator, each EPA regional office is responsible within its states for implementing the Agencys programs, except those programs that have been specifically delegated to states
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National Historic Chemical Landmarks
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The National Historic Chemical Landmarks program was launched by the American Chemical Society in 1992 to recognize seminal achievements in the history of chemistry and related professions. The program celebrates the centrality of chemistry, bakelite, the worlds first completely synthetic plastic, developed by Leo Baekeland around 1907 Chandler Chemistry Laboratory at Lehigh University, constructed in 1884 Joseph Priestley House, U. S. S. A. Pfizer & Co. Inc. and E. R. K, mellon to conduct scientific research and train industrial researchers The R. B. Izaak Maurits Kolthoffs role in establishing the discipline of analytical chemistry at the University of Minnesota in Minneapolis. The research and professional contributions of Rachel Holloway Lloyd, the first American woman to receive a Ph. D. in chemistry, at the University of Nebraska-Lincoln where she taught. William Kellys pneumatic iron refining process, patented in 1857, at the Lyon County Public Library in Eddyville, Kentucky, lands invention of instant photography, at the former Polaroid Corporation Laboratory in Cambridge, Massachusetts. The discovery and isolation of phytochrome, a pigment in plants that controls their germination, growth. Phytochrome was isolated in 1959 at the U. S. Department of Agricultures Beltsville Area Research Center in Beltsville, willard Libbys discovery of radiocarbon dating at the University of Chicago
22.
PubChem
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PubChem is a database of chemical molecules and their activities against biological assays. The system is maintained by the National Center for Biotechnology Information, a component of the National Library of Medicine, PubChem can be accessed for free through a web user interface. Millions of compound structures and descriptive datasets can be downloaded via FTP. PubChem contains substance descriptions and small molecules with fewer than 1000 atoms and 1000 bonds, more than 80 database vendors contribute to the growing PubChem database. PubChem consists of three dynamically growing primary databases, as of 28 January 2016, Compounds,82.6 million entries, contains pure and characterized chemical compounds. Substances,198 million entries, contains also mixtures, extracts, complexes, bioAssay, bioactivity results from 1.1 million high-throughput screening programs with several million values. PubChem contains its own online molecule editor with SMILES/SMARTS and InChI support that allows the import and export of all common chemical file formats to search for structures and fragments. In the text search form the database fields can be searched by adding the name in square brackets to the search term. A numeric range is represented by two separated by a colon. The search terms and field names are case-insensitive, parentheses and the logical operators AND, OR, and NOT can be used. AND is assumed if no operator is used, example,0,5000,50,10 -5,5 PubChem was released in 2004. The American Chemical Society has raised concerns about the publicly supported PubChem database and they have a strong interest in the issue since the Chemical Abstracts Service generates a large percentage of the societys revenue. To advocate their position against the PubChem database, ACS has actively lobbied the US Congress, soon after PubChems creation, the American Chemical Society lobbied U. S. Congress to restrict the operation of PubChem, which they asserted competes with their Chemical Abstracts Service
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ChemSpider
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ChemSpider is a database of chemicals. ChemSpider is owned by the Royal Society of Chemistry, the database contains information on more than 50 million molecules from over 500 data sources including, Each chemical is given a unique identifier, which forms part of a corresponding URL. This is an approach to develop an online chemistry database. The search can be used to widen or restrict already found results, structure searching on mobile devices can be done using free apps for iOS and for the Android. The ChemSpider database has been used in combination with text mining as the basis of document markup. The result is a system between chemistry documents and information look-up via ChemSpider into over 150 data sources. ChemSpider was acquired by the Royal Society of Chemistry in May,2009, prior to the acquisition by RSC, ChemSpider was controlled by a private corporation, ChemZoo Inc. The system was first launched in March 2007 in a release form. ChemSpider has expanded the generic support of a database to include support of the Wikipedia chemical structure collection via their WiChempedia implementation. A number of services are available online. SyntheticPages is an interactive database of synthetic chemistry procedures operated by the Royal Society of Chemistry. Users submit synthetic procedures which they have conducted themselves for publication on the site and these procedures may be original works, but they are more often based on literature reactions. Citations to the published procedure are made where appropriate. They are checked by an editor before posting. The pages do not undergo formal peer-review like a journal article. The comments are moderated by scientific editors. The intention is to collect practical experience of how to conduct useful chemical synthesis in the lab, while experimental methods published in an ordinary academic journal are listed formally and concisely, the procedures in ChemSpider SyntheticPages are given with more practical detail. Comments by submitters are included as well, other publications with comparable amounts of detail include Organic Syntheses and Inorganic Syntheses
