Chemistry is the first collaborative studio album by American rapper Buckshot and record producer 9th Wonder. It was released on June 21, 2005 through Duck Down Music as a part of the label's "Triple Threat Campaign", preceded by Sean Price's Monkey Barz and followed by Tek & Steele's Smif 'n' Wessun: Reloaded. Recording sessions took place at Missie Ann Studios in Raleigh, North Carolina. Production was handled entirely by 9th Wonder, with Buckshot and Drew "Dru-Ha" Friedman serving as executive producers. It features guest appearances from Keisha Shontelle, Big Pooh, Joe Scudda, L.E.G.A.C.Y., Phonte, Sean Price and Starang Wondah. This album is paralleled by the Black Moon album Alter the Chemistry, which was basically a remix album produced by Da Beatminerz.

Kenyatta Blake, known professionally as Buckshot, is an American rapper from New York, best known as a frontman of hip hop groups Black Moon and Boot Camp Clik. He rose to prominence with Black Moon's debut 1993 album Enta da Stage, which is critically acclaimed and influential in hip-hop.