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Chen Yi (Kuomintang)

Chen Yi was the chief executive and garrison commander of Taiwan Province after the Empire of Japan surrendered to the Republic of China. He acted on behalf of the Allied Powers to accept the Japanese Instrument of Surrender in Taipei Zhongshan Hall on October 25, 1945, he is considered to have mismanaged the tension between the Taiwanese and Mainland Chinese which resulted in the February 28 Incident in 1947, was dismissed. In June 1948 he was appointed Chairman of Zhejiang Province, but was dismissed and arrested when his plan to surrender to the Chinese Communist Party was discovered, he was sentenced to death and executed in Taipei in 1950. Chen was born in Zhejiang during the Qing dynasty. After studying at Qiushi Academy, in 1902 he went to a military academy in Japan for seven years, he joined Guangfuhui while in Japan. He returned to Japan in 1917 to study in a military university for three years resided in Shanghai, he is said to have been a "Japanophile."He was the first senator and governor of Zhejiang.

Chen was the commander of the 19th Route Army of the National Revolutionary Army. After 1927, he worked in the Military Affairs Department as the chairman of Fujian in 1933, Secretary-General of the Executive Yuan. Chen served as governor of Fujian province for eight years, beginning in 1934, his experience in Fujian, the province across the Taiwan Strait and the source of a larger percentage of Taiwan's population, was a factor in Chen's selection to take control of Taiwan at the end of the war. During his tenure in Fujian, Chen got a taste of the complexity of ethnic and social ties among people from Fujian in other parts of Asia, he ran afoul of a powerful Chinese in Singapore, Tan Kah Kee, the leader of a large community of overseas Chinese. As a result of the conflict, Chen had to spend considerable effort and political capital fending off accusations of maladministration made against him by the influential Tan. In 1935, Chen was sent to Taiwan by Chiang Kai-shek to attend "Exposition to Commemorate the 40th Anniversary of the Beginning of Administration in Taiwan," an exposition which served as a report on the achievements of Taiwan's modernization process under Japanese rule.

During his stay in Taiwan, he praised the modern public facilities and the strong economic development. Chen publicly expressed his admiration with jealousy about the advanced life quality Taiwanese people enjoyed compared with the Chinese mainlanders who suffered from prolonged war incurred destruction and lack of further modernization. After he went back to Fujian, he filed a report to Chiang Kai-shek about his visit. With his experience in Japan and Taiwan, Chen had become the first candidate as the Taiwan governor in Chiang's mind after Japan relinquished the sovereignty of Taiwan. Under the authorization of Douglas MacArthur's General Order No. 1, Chen Yi was escorted by George Kerr to Taiwan for accepting Japan government's surrender as the Chinese delegate. On October 25, 1945, joined by delegates from Allied Powers, Chen signed a surrender instrument with General Ando Rikichi, governor-general of Taiwan, in Taipei City Hall. Chen Yi proclaimed that day to be the Taiwan Retrocession Day, regarded as controversial as Japan had not yet ceded Taiwan in any treaty until 1952.

Native Taiwanese, who were anti-Communist and supportive of the KMT, cheered the retrocession, believing their exports could now be directed to help China rather than Japan. The local elites established "Preparatory Committees to Welcome the National Government", to help distribute promotional materials on behalf of the Chinese Nationalists. Chen did receive some praise for his dedication to work, his frugality, incorruptibility, he was, criticized for his support for his more corrupt subordinates, his stubborn lack of flexibility in some policies. Despite fluency in Japanese, he refused to use the language to interact with local Taiwanese elites, many of whom could not speak Mandarin, believing that the island must abandon the colonial language in favor of the new national tongue; this inability to communicate with his subjects and the fact he made little effort to leave his official offices and interact with the Taiwanese society he ruled over made it difficult for him to detect the growing unrest on the island after the first year of postwar rule.

Chen was removed from the position of Taiwan governor general for his mishandling of the administration of Taiwan. Chen's policies led to the 228 Incident of 1947, during the brutal suppression of local protests that erupted after the 228 Incident, an estimated 5,000 to 28,000 local and non-local Taiwanese civilians were killed. In the early years of KMT Chinese rule of Taiwan, rampant corruption in the new administration headed by Chen caused high unemployment rates, widespread disease, severe inflation, which in turn led to widespread local discontent. In addition, new policies announced in early 1947 further enraged locals: direct elections would be delayed until late 1949, despite the adoption of the Chinese Constitution in 1947. Allegations of carpet bagging by new immigrants from the mainland and a breakdown in social and governmental services served to increase tensions; as the Shanghai newspaper Wenhui Bao remarked, Chen ran

Sacred Heart College (Lucena)

Sacred Heart College is an educational institution in Lucena City, Philippines. The first catholic learning institution in Quezon Province, it was founded on April 27, 1884, it had its roots in the vision of a simple and saintly woman named Hermana Fausta Labrador whose exemplary life was moulded on the Vincentian spirituality. The school grew and its status was changed from Academy to College in 1941, it was formally turned-over to the Daughters of Charity of Saint Vincent de Paul on August 14, 1937. In 2009, Sacred Heart College celebrated its 125th founding anniversary; the school's basic education division offers primary and secondary education from kindergarten through grade 12. The higher education division offers courses leading to associate degrees, bachelor's degrees, master's degrees. Sacred Heart College, the oldest Catholic institution for men and women in Quezon Province, was founded on April 27, 1884; the school had its roots in the vision of a simple and saintly woman named Hermana Fausta Labrador who, at the age of 26, opened a Charity school to form the youth according to the ideals of the Catholic faith.

The mission of Hermana Uta, as she was fondly called, obtained its first shapes through Don Gregorio Merchan, a wealthy citizen of Lucena, who offered his house to serve as the first school building on April 27, 1884. Having been trained and molded by the Daughters of Charity at the Colegio de Santa Rosa, Hermana Uta decided to leave her school in the hands of the Daughters of Charity in the twilight handed over to the Sisters on August 14, 1937. In 1939, the school was operating the complete primary and high school courses. Realizing the need for the good teachers founded on solid Christian ideals, the sisters deemed it necessary to open a teacher-training course. So in 1941, the school offered the Junior Normal Courses. With the opening of the new course, the status of the school was changed from Academy to College; the outbreak of the war in December 1941 forced the temporary closure of the school. The school reopened in July 1942 during the Japanese occupation. On September 14, 1942, at the age of 84, the saintly Foundress of Sacred Heart College died.

But her spirit continues to live to this day in the hearts of the people she had impressed with her mission. It seemed that not the conflagration that swept the first school building on June 11, 1944 could kill the spirit of utter selflessness. From the house of Don Gregorio Merchan to the residence of Don Agaton Rodriguez to the house of Atty. Fabian Millar to the Club X building to the present school site the spirit of the Foundress continues to permeate the corridors, the hall, the grounds and the chapel. With the construction of the present school building, the former site of the school razed down by the big fire that hit Lucena in 1965 was transformed into a landmark; the Hermana Fausta Development Center has become the center of the school's community outreach projects for the depressed sectors of the community. In 1982, the Basic Education Department took that bold step towards academic excellence by undergoing and passing the rigid requirements for accreditation of the Philippine Accrediting Association of Schools and Universities.

In 1993, the Higher Education Department made its own bid for PAASCU accreditation, passing the Preliminary Survey and the Formal Survey in February 1998. Sacred Heart College HED is PAASCU Accredited School. In the area of physical development, the school in the last two decades has constructed and/or developed other landmarks such as the school gymnasium 1984, the Sto. Nino Building and the St. Vincent Hall in 1993, the John Paul II Youth Formation House along with the TwinHearts Ecology Park in 1994, a three-story building for the Basic Education Department in 1997 and the SHC Cultural Center and Gymnasium in 1999. To meet the needs and challenges of the times, the school has opened new courses and majors in the Higher Education Departments such as AB Communications, AB Psychology, BS Computer Science, Computer Secretarial. On top of these significant developments is the opening of a graduate program in Master of Arts in Education. "The Pulse" is the formal publication name of the Lower Integrated Basic Education Department, "The Heartbeat" for the Higher Integrated Basic Education Department and "The Heart" for the Higher Education Department.

College of Business Administration,Accountancy & Computer Science: Mr. Arnel L. Cadelina College of Liberal Arts and General Education: Dr. Leonora Y. Paleracio College of Nursing and Pharmacy: Mrs. Amelia Vargas College of Social Work: Sr. Aubrey Casimiro http://www. SHC.edu.ph/ Sacred Heart College Lucena City Schools and University

Major royal jelly protein

Major royal jelly proteins are a family of proteins secreted by honey bee. The family consists of nine proteins, of which MRJP1, MRJP2, MRJP3, MRJP4, MRJP5 are present in the royal jelly secreted by worker bees. MRJP1 is the most abundant, largest in volume; the five proteins constitute 82-90% of the total proteins in a royal jelly. Royal jelly is a nutrient-rich mixture of vitamins, fats and enzymes, it is used for feeding the larvae. Royal jelly has been used in traditional medicine since ancient times, the MRJPs are shown to be the main medicinal components, they are synthesised by a family of nine genes, which are in turn members of the yellow family of genes such as in the fruitfly and bacteria. They are attributed to be involved in differential development of queen larva and worker larvae, thus establishing division of labour in the bee colony; the chemical investigation on royal jelly started in the 1960s. Jozef Hanes and Jozef Šimuth, of the Slovak Academy of Sciences, were the first to identify major royal jelly protein from the hypopharyngeal glands.

In 1992 they isolated the protein as a complex of two molecules. MRJP1 as a single molecule was first isolated by Masaki Kamakura and his team at the Toyama Prefectural University in 2001, he found two proteins as potential markers for freshness of royal jelly protein and named them royal jelly proteins. RJP-1 was a 57-kDa monomer, a subunit of a larger complex. In 2011, Kamakura discovered that RJP-1 is the main protein for controlling larval development that distinguishes the queen from workers, he gave a new name royalactin. In 1994, Hanes and Šimuth's team identified genes called pRJP57–1 and pRJP57–2 from the bee head and found that these genes produce similar protein to the first MRJP. By 1999, several independent scientists confirmed the existence of five MRJPs; the Honeybee Genome Sequencing Consortium reported in 2006. MRJP1 is the most abundant protein in royal jelly, it can exists as monomer and as oligomer. The molecular size of the oligomer is 290-350 kDa; the oligomer is a combination of five monomers.

The monomers are associated with another protein apimisin. The monomer is 55 kDa in mass; the monomer contains 432 amino acids, is divisible into three chains, such as jellein-1, jellein-2, jellein-4. The monomers in the ologomer are held together by apimisin using noncovalent bonds; the oligomer is resistant to high temperature. MRJP2, MRJP3, MRJP4 and MRJP5 are smaller and their size range between 49 and 80 kDa. All MRJPs are synthesised from the hypopharyngeal glands, except for MRJP8. MRJP8 is produced in the head of nurse bees by the Kenyon cells in the mushroom bodies, it was earlier established. But research showed that mrjp genes are expressed in forager and the queen, not only in their hypopharynx, but in their brains and abdomen. Mrjp1-7 are expressed in the heads of worker bees, with a higher activity of mrjp1-4 and mrjp7 in nurse bees compared to foragers. In contrast, mrjp5 and mrjp6 are more active in foragers compared. Mrjp9 is active in the heads and abdomen of all female bees; this indicates.

The mrjp1 gene contains six exons separated by five introns. As a major component of the royal jelly, MRJPs are the primary proteins in the diet of bee larvae. Other than their nutritional value, their exact biological function is yet to be confirmed; the first important discovery was made by Masaki Kamakura in 2011, who found that MRJP1 controls division of labour. Kamakura showed that MRJP1 is the main factor for differentiation of the queen larva from worker larvae. In the queen larva, MRJP1 induces faster growth, juvenile hormone secretion and development of ovary, while reducing the maturation period. Under experimental condition, fruitfly larvae are affected by MRJP1. MRJP1 acts through signalling pathways such as p70-S6 kinase, mitogen-activated protein kinase, epidermal growth factor, but researchers at the Martin Luther University of Halle-Wittenberg reported in 2016 that MRJP1 alone is not the main protein, but MRJP2, MRJP3, MRJP5 are important in the larval development of the queen.

MRJPs are used in the pharmaceutical and cosmetic fields, are commercialised as an over-the-counter food supplements. They have antimicrobial activities against bacteria and viruses, they show an ability to lower blood pressure, fats in the blood, stop tumour growth in vitro, anti-inflammation. Royal jelly has been associated with allergic reactions such as contact dermatitis, acute asthma, anaphylaxis, which can lead to death. In a clinical diagnosis, MRJP1 and MRJP2 are found to be the main allergens, they induce IgE-mediated hypersensitivity reactions thereby causing type 1 hypersensitivity. Profile at UniProt Profile at InterPro