Cherokee County is a U.S. county located in Southeast Kansas. Its county seat is Columbus, and its most populous city is Baxter Springs. As of the 2020 census, the county population was 19,362. The county was named for the Cherokee tribe.

Columbus is the second largest city and county seat of Cherokee County, Kansas, United States. As of the 2020 census, the population of the city was 2,929. It is located approximately 15 miles south-southwest of Pittsburg.