Cherokee County is a county located in the U.S. state of Oklahoma. As of the 2020 census, the population was 47,078. Its county seat is Tahlequah, which is also the capital of the Cherokee Nation.

Tahlequah is a city in Cherokee County, Oklahoma located at the foothills of the Ozark Mountains. It is part of the Green Country region of Oklahoma and was established as a capital of the 19th-century Cherokee Nation in 1839, as part of the new settlement in Indian Territory after the Cherokee Native Americans were forced west from the American Southeast on the Trail of Tears.