Chesapeake is a village in Lawrence County, Ohio, United States. The population was 691 as of the 2020 census. It lies across the Ohio River from Huntington, West Virginia, at the mouth of Symmes Creek.

Lawrence County is the southernmost county of the U.S. state of Ohio. As of the 2020 census, the population was 58,240. Its county seat is Ironton. The county was created in 1815 and later organized in 1817. It is named for James Lawrence, the naval officer famous for the line "do not give up the ship". Lawrence County is part of the Huntington–Ashland metropolitan area.