The Chesapeake and Ohio Railway was a Class I railroad formed in 1869 in Virginia from several smaller Virginia railroads begun in the 19th century. Led by industrialist Collis P. Huntington, it reached from Virginia's capital city of Richmond to the Ohio River by 1873, where the railroad town of Huntington, West Virginia, was named for him.

Hampton Roads is the name of both a body of water in the United States that serves as a wide channel for the James, Nansemond, and Elizabeth rivers between Old Point Comfort and Sewell's Point near where the Chesapeake Bay flows into the Atlantic Ocean, and the surrounding metropolitan region located in the southeastern Virginia and northeastern North Carolina portions of the Tidewater Region.