Chesterfield Street is a "virtually intact" Georgian street in London's Mayfair district. Several of the buildings are Grade II listed on the National Heritage List for England.

Chesterfield House was a grand London townhouse built between 1747 and 1752 by Philip Stanhope, 4th Earl of Chesterfield (1694–1773), statesman and man of letters. The exterior was in the Palladian style, the interior Baroque. It stood in Mayfair on the north side of Curzon Street, between South Audley Street and what is now Chesterfield Street. It was demolished in 1937 and on its site now stands a block of flats of the same name.