The Chicago–Kansas City Expressway is a highway that runs between Chicago, Illinois, and Kansas City, Missouri. The road is known as Route 110 in Missouri and Illinois Route 110 (IL 110) in Illinois. IL 110 was created through legislation on May 27, 2010, as the designated route for the Illinois portion of the Chicago–Kansas City Expressway.

Hannibal is a city along the Mississippi River in Marion and Ralls counties in the U.S. state of Missouri. According to the 2020 U.S. Census, the population was 17,312, making it the largest city in Marion County. The bulk of the city is in Marion County, with a tiny sliver in the south extending into Ralls County.