Two grand opera companies in Chicago, Illinois, have gone by the name Chicago Grand Opera Company during the first half of the 20th century. Like many opera ventures in Chicago, both succumbed to financial difficulties within a few years, and it wasn't until 1954 that a lasting company was formed in the city.

Luisa Tetrazzini was an Italian dramatic coloratura soprano of great international fame. Tetrazzini "had a scintillating voice with a brilliant timbre and a range and agility well beyond the norm...". She enjoyed a highly successful operatic and concert career in Europe and America from the 1890s through to the 1920s. Her voice lives on in recordings made from 1904–1920. She wrote a memoir, My Life of Song, in 1921 and a treatise, How to Sing, in 1923. After retirement, she taught voice in her homes in Milan and Rome until her death.