The sixth season of Chicago Med, an American medical drama television series with executive producer Dick Wolf, and producers Michael Brandt, Derek Haas, Peter Jankowski, Andrew Schneider and Diane Frolov, was ordered on February 27, 2020. The season premiered on November 11, 2020. This season marks the final appearances of paediatric attending Natalie Manning portrayed by Torrey DeVitto and staff nurse April Sexton portrayed by Yaya DaCosta.

Chicago Med is an American medical drama television series created by Dick Wolf and Matt Olmstead, and is the third installment of Wolf Entertainment's Chicago franchise. The series premiered on NBC on November 17, 2015. Chicago Med follows the emergency department (ED) doctors and nurses of the fictional Gaffney Chicago Medical Center. As they work to save lives, these members deal with the personal and professional pressures of their jobs.