Chicago Union Station is an intercity and commuter rail terminal located in the West Loop neighborhood of the Near West Side of Chicago. Amtrak's flagship station in the Midwest, Union Station is the terminus of eight national long-distance routes and seven regional corridor routes. Six Metra commuter lines also terminate here.

The Near West Side, one of the 77 community areas of Chicago, is on the West Side, west of the Chicago River and adjacent to the Loop. The Great Chicago Fire of 1871 started on the Near West Side. Waves of immigration shaped the history of the Near West Side of Chicago, including the founding of Hull House, a prominent settlement house. In the 19th century railroads became prominent features. In the mid-20th century, the area saw the development of freeways centered in the Jane Byrne Interchange.