Chichicastenango, also known as Santo Tomás Chichicastenango, is a town, with a population of 71,394, and the municipal seat for the surrounding municipality of the same name in the El Quiché department of Guatemala. It is located in a mountainous region about 140 km (87 mi) northwest of Guatemala City, at an altitude of 1,965 m (6,447 ft). The Spanish conquistadors gave the town its name from the Nahuatl name used by their allied soldiers from Tlaxcala: Tzitzicaztenanco, or City of Nettles. Its original name was Chaviar.

Quiché is a department of Guatemala. It is in the heartland of the Kʼicheʼ (Quiché) people, one of the Maya peoples, to the north-west of Guatemala City. The capital is Santa Cruz del Quiché. The word Kʼicheʼ comes from the language of the same name, which means "many trees".