The Chihuahuan Desert is a desert ecoregion designation covering parts of northern Mexico and the southwestern United States. It occupies much of far West Texas, the middle to lower Rio Grande Valley and the lower Pecos Valley in New Mexico, and a portion of southeastern Arizona, as well as the central and northern portions of the Mexican Plateau. It is bordered on the west by the Sonoran Desert, the Colorado Plateau, and the extensive Sierra Madre Occidental range, along with northwestern lowlands of the Sierra Madre Oriental range. Its largest, continual expanse is located in Mexico, covering a large portion of the state of Chihuahua, along with portions of Coahuila, north-eastern Durango, the extreme northern part of Zacatecas, and small western portions of Nuevo León. With an area of about 501,896 km2 (193,783 sq mi), it is the largest hot desert in North America. The desert is fairly young, existing for only 8000 years.

The Central Mexican Plateau, also known as the Mexican Altiplano, is a large arid-to-semiarid plateau that occupies much of northern and central Mexico. Averaging 1,825 m (5,988 ft) above sea level, it extends from the United States border in the north to the Trans-Mexican Volcanic Belt in the south, and is bounded by the Sierra Madre Occidental and Sierra Madre Oriental to the west and east, respectively.