The Chihuahuan Desert is a desert ecoregion designation covering parts of northern Mexico and the southwestern United States. It occupies much of far West Texas, the middle to lower Rio Grande Valley and the lower Pecos Valley in New Mexico, and a portion of southeastern Arizona, as well as the central and northern portions of the Mexican Plateau. It is bordered on the west by the Sonoran Desert, the Colorado Plateau, and the extensive Sierra Madre Occidental range, along with northwestern lowlands of the Sierra Madre Oriental range. Its largest, continual expanse is located in Mexico, covering a large portion of the state of Chihuahua, along with portions of Coahuila, north-eastern Durango, the extreme northern part of Zacatecas, and small western portions of Nuevo León. With an area of about 501,896 km2 (193,783 sq mi), it is the largest hot desert in North America. The desert is fairly young, existing for only 8000 years.

The Southwestern United States, also known as the American Southwest or simply the Southwest, is a geographic and cultural region of the United States that includes Arizona and New Mexico, along with adjacent portions of California, Colorado, Nevada, Oklahoma, Texas, and Utah. The largest cities by metropolitan area are Phoenix, Las Vegas, El Paso, Albuquerque, and Tucson. Before 1848, in the historical region of Santa Fe de Nuevo México as well as parts of Alta California and Coahuila y Tejas, settlement was almost non-existent outside of Nuevo México's Pueblos and Spanish or Mexican municipalities. Much of the area had been a part of New Spain and Mexico until the United States acquired the area through the Treaty of Guadalupe Hidalgo in 1848 and the smaller Gadsden Purchase in 1854.