Christina of Lorraine was a French noblewoman of the House of Lorraine who became a Grand Duchess of Tuscany by marriage. She served as Regent of Tuscany jointly with her daughter-in-law during the minority of her grandson from 1621 to 1628.

The Grand Duchy of Tuscany was an Italian monarchy that existed, with interruptions, from 1569 to 1860, replacing the Republic of Florence. The grand duchy's capital was Florence. In the 19th century the population of the Grand Duchy was about 1,815,000 inhabitants.