Charles Lee "Chucky" Ray is the main antagonist of the Child's Play horror franchise. Chucky is portrayed as a vicious serial killer who, as he bleeds out from a gunshot wound, transfers his soul into a "Good Guy" doll and continuously tries to transfer it to a human body. The character has become one of the most recognizable horror icons and has been referenced numerous times in popular culture. In 1999, the Chucky character was nominated for the MTV Movie Award for Best Villain for the film Bride of Chucky. He was created by writer Don Mancini and is portrayed by Brad Dourif in both live action and voice over. For the 2019 remake of the same name, Mark Hamill voiced an artificial intelligence (AI) version of Chucky as a tragic villain, having previously voiced the Charles Lee Ray version of the character in an episode of Robot Chicken.

Tiffany Valentine is a murderous doll and the secondary antagonist in the Child's Play horror film series. She is portrayed by Jennifer Tilly in both live-action and voice over in Bride of Chucky, Seed of Chucky, Curse of Chucky, Cult of Chucky, and Chucky.