The Church of St Margaret of Antioch is in Prince's Road, Toxteth, Liverpool, England. It is an active Anglican parish church in the diocese of Liverpool, the archdeaconry of Liverpool, and the deanery of Toxteth and Wavertree. The church is recorded in the National Heritage List for England as a designated Grade II* listed building.

The Horsfall family was a family notable in Liverpool, UK, especially as traders at the heart of British trade with Africa after 1807, and as religious benefactors whose churches are among the most important religious buildings in the city.