The Church of the Nazarene is a Christian denomination that emerged in North America from the 19th-century Wesleyan-Holiness movement within Methodism. It is headquartered in Lenexa, Kansas. With its members commonly referred to as Nazarenes, it is the largest denomination in the world aligned with the Wesleyan-Holiness movement and is a member of the World Methodist Council.

The Holiness movement is a Christian movement that emerged chiefly within 19th-century Methodism, and to a lesser extent influenced other traditions such as Quakerism, Anabaptism, and Restorationism. The movement is historically distinguished by its emphasis on the doctrine of a second work of grace, which is called entire sanctification or Christian perfection. Churches aligned with the holiness movement additionally teach that the Christian life should be free of sin. For the Holiness movement, "the term 'perfection' signifies completeness of Christian character; its freedom from all sin, and possession of all the graces of the Spirit, complete in kind." A number of evangelical Christian denominations, parachurch organizations, and movements emphasize those beliefs as central doctrine.